TY - JOUR
T1 - The effects of lead acetate exposure on blood component and kidney
T2 - The mechanism of oxidative stress
AU - Sugiharto,
AU - Darmanto, Win
AU - Sri Puji Astuti, W.
AU - Putri, Kevita
AU - Khoirunnisa, Nur
AU - Mulyawan, Dea B.
AU - Shanti, Arin N.
N1 - Funding Information:
We would like to thank to Faculty Sciences and Technology, Universitas Airlangga, for research grant No.1915/UN3.1.8/LT/2018.
Publisher Copyright:
© EM International.
PY - 2020
Y1 - 2020
N2 - Lead (Pb) may induce oxidative stress and it can increase the production of free radicals. Lead exposure increased of malondialdehyde (MDA) and reduced superoxide dismutase (SOD) level in mice blood serum and increased lead levels in the liver. It can induce several responses in physiological and biochemical functions of the body, especially to biochemical of blood components and kidney. The objective of this research was to evaluate the effect of lead acetate exposure on levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hemoglobin (Hb) concentration, the number of red blood cells (RBC), also glomeruli kidney in mice. Research was conducted using eighteen male mice, which were grouped into three treatments: P1 (control), P2 (Pb 75 mg/kg BW), P3 (Pb 150 mg/kg BW). The results showed that to compare the control group, lead exposure significantly shift to enzyme ALT levels, Hb concentration, RBC numbers, percentages of glomeruli (especially in normal, swollen, and contracted glomeruli), Bowman’s capsule diameters, and glomeruli – Bowman’s ratio. On the contrary, the AST levels and glomeruli diameter are insignificantly compared to the control group.
AB - Lead (Pb) may induce oxidative stress and it can increase the production of free radicals. Lead exposure increased of malondialdehyde (MDA) and reduced superoxide dismutase (SOD) level in mice blood serum and increased lead levels in the liver. It can induce several responses in physiological and biochemical functions of the body, especially to biochemical of blood components and kidney. The objective of this research was to evaluate the effect of lead acetate exposure on levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hemoglobin (Hb) concentration, the number of red blood cells (RBC), also glomeruli kidney in mice. Research was conducted using eighteen male mice, which were grouped into three treatments: P1 (control), P2 (Pb 75 mg/kg BW), P3 (Pb 150 mg/kg BW). The results showed that to compare the control group, lead exposure significantly shift to enzyme ALT levels, Hb concentration, RBC numbers, percentages of glomeruli (especially in normal, swollen, and contracted glomeruli), Bowman’s capsule diameters, and glomeruli – Bowman’s ratio. On the contrary, the AST levels and glomeruli diameter are insignificantly compared to the control group.
KW - Blood component
KW - Kidney
KW - Lead
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85089421146&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85089421146
SN - 0971-765X
VL - 26
SP - S65-S69
JO - Ecology, Environment and Conservation
JF - Ecology, Environment and Conservation
ER -