The effects of lead acetate exposure on blood component and kidney: The mechanism of oxidative stress

Sugiharto, Win Darmanto, W. Sri Puji Astuti, Kevita Putri, Nur Khoirunnisa, Dea B. Mulyawan, Arin N. Shanti

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Lead (Pb) may induce oxidative stress and it can increase the production of free radicals. Lead exposure increased of malondialdehyde (MDA) and reduced superoxide dismutase (SOD) level in mice blood serum and increased lead levels in the liver. It can induce several responses in physiological and biochemical functions of the body, especially to biochemical of blood components and kidney. The objective of this research was to evaluate the effect of lead acetate exposure on levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hemoglobin (Hb) concentration, the number of red blood cells (RBC), also glomeruli kidney in mice. Research was conducted using eighteen male mice, which were grouped into three treatments: P1 (control), P2 (Pb 75 mg/kg BW), P3 (Pb 150 mg/kg BW). The results showed that to compare the control group, lead exposure significantly shift to enzyme ALT levels, Hb concentration, RBC numbers, percentages of glomeruli (especially in normal, swollen, and contracted glomeruli), Bowman’s capsule diameters, and glomeruli – Bowman’s ratio. On the contrary, the AST levels and glomeruli diameter are insignificantly compared to the control group.

Original languageEnglish
Pages (from-to)S65-S69
JournalEcology, Environment and Conservation
Volume26
Publication statusPublished - 2020

Keywords

  • Blood component
  • Kidney
  • Lead
  • Oxidative stress

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