Lactobacillus plantarum IS-10506 (LIS-10506) is a native Indonesian probiotic derived from fermented milk originating from Sumatera. Intestinal mucosa damage results from gastrointestinal tract infections. Using Scanning Electron Microscopy (SEM), the intestinal mucosa structure, following mucosal damage, was evaluated. The objective of this study to evaluate effect of Lactobacillus plantarum IS-10506 on accelerating the regeneration of the intestinal mucosa structure, using SEM. This study conducted on sixty-four Sprague-Dawley rats were divided into 4 groups: control group (K1); the group that received Lipopolysaccharide (LPS) Escherichia coli O55:B5 (K2); the curative group, which received LPS Escherichia coli O55:B5 then probiotics (K3); the preventive group, which received probiotics six days before LPS Escherichia coli O55:B5 and continued probiotics (K4). The probiotics used were LIS-10506. Necroscopy was performed on days 3, 4, 6 and 7, and the ileum was analysed. SEM was conducted to evaluate the structure of the intestinal mucosa. SEM showed that the K4 group experienced the fastest mucosal regeneration on the fourth day. On the seventh day, examination of the ileum using SEM showed improvement in the intestinal villi of all groups. The conclusion, SEM showed that all groups underwent regeneration following mucosal damage. Probiotics accelerated the regeneration of the intestinal mucosa, and the best results were observed in the preventive group.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalCarpathian Journal of Food Science and Technology
Issue number5
Publication statusPublished - 2019


  • Intestinal mucosa
  • Probiotics
  • Regeneration
  • Scanning electron microscope (SEM)


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