The effects of honey (Apis dorsata) supplements on increased bone strength in ovariectomized rat as animal model of osteoporosis

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Abstract

Osteoporosis is a chronic skeletal disease characterized by low bone mass and microarchitectural deterioration with a consequent increase in bone fragility and fracture risk. The aim of the study was to evaluate the effects of honey (Apis dorsata) supplements on increased bone strength in ovariectomized rat as animal models of osteoporosis. Twenty female rats at 3 months of age, weighing 150-200 g were used in the study. The rats were divided into five groups (n=4): Sham operation group (SH); ovariectomy group no treatment(OVX); ovariectomy with treatment Apis dorsata 1g/Kg BW (AD-1); ovariectomy with treatment Apis dorsata 2g/Kg BW (AD-2); ovariectomy with treatment Apis dorsata 4g/Kg BW (AD-3). The treatment started to be given the next day after ovariectomy operation for 12 weeks. The Rats were sacrified within 12 weeks, and then the right femur were taken bone strength test. Based on the statistical analysis of the bone strength test, the greatest score belongs to the Sham operation group (SH) that have significant difference (p<0.05) with OVX group and AD-1 group, but there was no significant difference with AD-2 and AD-3 (p>0,05). In conclusion, honey (Apis dorsata) supplements has the effect of increasing bone strength in ovariectomized rat as animal models of osteoporosis, so that honey (Apis dorsata) supplements has the potential to be used as an alternative treatment for osteoporosis.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Conference on Materials and Metallurgical Engineering and Technology, ICOMMET 2017
Subtitle of host publicationAdvancing Innovation in Materials Science, Technology and Applications for Sustainable Future
EditorsMas Irfan P. Hidayat
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735416406
DOIs
Publication statusPublished - 3 Apr 2018
Event3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017 - Surabaya, Indonesia
Duration: 30 Oct 201731 Oct 2017

Publication series

NameAIP Conference Proceedings
Volume1945
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Materials and Metallurgical Engineering and Technology: Advancing Innovation in Materials Science, Technology and Applications for Sustainable Future, ICOMMET 2017
Country/TerritoryIndonesia
CitySurabaya
Period30/10/1731/10/17

Keywords

  • Honey (Apis dorsata)
  • Osteoporosis
  • bone strength
  • ovariectomized rat

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