The effects of Curcuma Longa extract on fibroblast count and collagen density in left colon anastomosis with acute intra operative loss of 15% circulating blood volume in rats

Introduction: Intestinal anastomosis leakage is a significant concern following intestinal suturing due to its potential to cause morbidity and mortality. Curcuma longa, commonly known as turmeric, has been observed to have wound-healing properties by promoting collagen deposition and increasing the number of fibroblasts. However, the effect of Curcuma longa on left colon anastomosis with acute intra operative loss of 15% circulating blood volume is unknown. This study aimed to determine the impact of oral administration of Curcuma longa extract on the number of fibroblasts and collagen density in the left colon anastomosis with acute intraoperative loss of 15% circulating blood volume. Methods: This is an experimental study; the researchers investigated the effect of Curcuma longa extract on the healing process of colon anastomosis in white rats-Rattus norvegicus. Results: A total of 30 white rats-Rattus norvegicus underwent laparotomy for left colon anastomosis resection, and they were randomly divided into two groups. One group was given Curcuma longa extract orally after surgery, and the other group did not received it. After five days of treatment, the group that received Curcuma longa extract orally had a significantly higher mean number of fibroblasts (1168.13) compared to the control group (749.60) (p-value: 0.006). Moreover, the collagen density in the treated group was also higher, with a density range of 50-72% (60% of rats) and 75-100% (33.30% of rats), compared to the control group’s density range of 25-50% (66.70% of rats) and 10-25% (13.30% of rats) (p-value: 0.000). Conclusion: Oral administration of Curcuma longa extract can increase the number of fibroblasts and collagen density in the left colon anastomosis with acute intra operative loss of 15% circulating blood volume.