TY - JOUR
T1 - The effects of amniotic membrane stem cell-conditioned medium on photoaging
AU - Prakoeswa, Cita Rosita Sigit
AU - Pratiwi, Febrina Dewi
AU - Herwanto, Nanny
AU - Citrashanty, Irmadita
AU - Indramaya, Diah Mira
AU - Murtiastutik, Dwi
AU - Sukanto, Hari
AU - Rantam, Fedik A.
N1 - Funding Information:
This study was supported by the Stem Cell Laboratory and Medical Faculty of Airlangga University.
Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/7/4
Y1 - 2019/7/4
N2 - Background: Photoaging is a complex biologic process that affects various layers of the skin with the major damage seen in the connective tissue of the dermis. Although rarely fatal, photoaging can significantly contribute to a loss of quality of life; therefore, it deserves attention. Researchers are continually searching for new compounds to develop rejuvenation therapies. Nowadays, the stem cell population has been discovered, and it shows capability to rejuvenate the skin. Material and methods: This was an analytic experimental research conducted on a total of 48 women who were randomized into two groups: 24 women received amniotic membrane stem cell-conditioned medium (AMSC-CM) and the other 24 women received normal saline (NS). We applied the drug for three times with an interval of 2 weeks. Microneedling was used to enhance epidermal penetration. We evaluated the progression of photoaging on Weeks 0, 4, and 8, as well as the side effects. Results: The improvement in photoaging after treatment showed significant better effects with the AMSC-CM than with NS (p <.05). There were minimal transient side effects in either of the study groups. Conclusion: AMSC-CM has the capability to improve clinical photoaging and is a promising option for rejuvenation therapy.
AB - Background: Photoaging is a complex biologic process that affects various layers of the skin with the major damage seen in the connective tissue of the dermis. Although rarely fatal, photoaging can significantly contribute to a loss of quality of life; therefore, it deserves attention. Researchers are continually searching for new compounds to develop rejuvenation therapies. Nowadays, the stem cell population has been discovered, and it shows capability to rejuvenate the skin. Material and methods: This was an analytic experimental research conducted on a total of 48 women who were randomized into two groups: 24 women received amniotic membrane stem cell-conditioned medium (AMSC-CM) and the other 24 women received normal saline (NS). We applied the drug for three times with an interval of 2 weeks. Microneedling was used to enhance epidermal penetration. We evaluated the progression of photoaging on Weeks 0, 4, and 8, as well as the side effects. Results: The improvement in photoaging after treatment showed significant better effects with the AMSC-CM than with NS (p <.05). There were minimal transient side effects in either of the study groups. Conclusion: AMSC-CM has the capability to improve clinical photoaging and is a promising option for rejuvenation therapy.
KW - epidermal penetration
KW - Microneedling
KW - rejuvenation therapy
KW - transient side effects
UR - http://www.scopus.com/inward/record.url?scp=85057226592&partnerID=8YFLogxK
U2 - 10.1080/09546634.2018.1530438
DO - 10.1080/09546634.2018.1530438
M3 - Article
C2 - 30265171
AN - SCOPUS:85057226592
SN - 0954-6634
VL - 30
SP - 478
EP - 482
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
IS - 5
ER -