The effectiveness of cynodon dactylon leaf extract as hepatoprotector in liver damage of hyperglycemic mus musculus

Background: The number of people with diabetes rises every day. Its treatment commonly causes significant side effects that can even cause damage to body organs, including liver. Herbal medicine development is currently carried out widely as in the Cynodon dactylon plant. C. dactylon plant contains antioxidant compounds and hepatoprotective effects. Purpose: The study aims to investigate hepatoprotective effect of C. dactylon leaf extract on liver histopathological changes of hyperglycemic Mus musculus and to investigate how much the dose of C. dactylon extract is most effective in protecting the liver. Method: Experimental animals, M. musculus, were set up in hyperglycemic condition by administrating 10% glucose with a dose of 2,000 mg/kg of body weight (bw), and administrating extract of C. dactylon leaves with the doses of 250 mg/kg bw; 500 mg/kg bw; 750 mg/kg bw; and 1,000 mg/kg bw. Then, observation on the results of M. musculus liver histopathology was conducted by a scoring method. Afterward, a statistical test was performed. Result: The most optimal hepatoprotective effect of C. dactylon extract was at the lowest administration dose of 250 mg/kg bw. This finding was evident from lowest scores for degeneration damage at 6.50 ± 0.00; necrosis damage at 6.00 ± 0.57; and inflammation rate at 7.13 ± 0.50. Conclusion: Extract of C. dactylon leaves has a hepatoprotective effect on the liver histopathological changes of hyperglycemic M. musculus.