The effectiveness comparison of desloratadine and loratadine in reducing total nasal symptom score and the level of interleukin 4 in the nasal secretions of allergic rhinitis patients

Luh Putu Dhena Purwaningsih, Dwi Reno Pawarti, Bakti Surarso

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background: Allergic rhinitis (AR) is a common atopic disease; however, the available therapy has limitation in the usage and its success rate. Desloratadine has a role as an alternative allergic rhinitis therapy to eliminate the overall symptoms of AR and reduce IL-4 level in nasal secretions. Method: This study was double-blind randomised clinical trial with pre-post test design. The data was analyzed by using independent sample t-test. There were 24 AR patients divided into 2 therapy groups which were study group (desloratadine) and control group (loratadine). The evaluation based on SGHT and IL-4 in nasal secretions was conducted pre and post 15 days of therapy. Results: The present study that was conducted on July-October 2016 showed significant difference in the average percentage of reduced TNSS in desloratadine group compared to loratadine group (p=0.000). The comparison of reduced level of IL-4 in nasal secretions between desloratadine and loratadine group was indicated insignificantly different. Conclusion: Reduced TNSS in desloratadine group was higher than in loratadine group. Also, there was no difference in decreased level of IL-4 in nasal secretions.

Original languageEnglish
Pages (from-to)1711-1716
Number of pages6
JournalIndian Journal of Forensic Medicine and Toxicology
Volume14
Issue number2
Publication statusPublished - 1 Apr 2020

Keywords

  • Allergic rhinitis
  • Desloratadine
  • Interleukin 4
  • Loratadine
  • Total nasal symptom score

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