One marine biota containing various proteins supporting enamel maturation is saltwater fish. Protein is transferred from a mother to her child through the placenta, an organ that plays a critical role in fetal growth and development. The placenta with fatty acid-binding proteins (FABPs) expression serves as an interface for exchanging substances, producing proper hormones during pregnancy, and as a barrier. Early dental enamel formation is generally known as amelogenesis. Type 1 collagen is one of the ameloblasts’ proteins in amelogenesis. This research aims to examine the effect of saltwater fish powder on the increase in the expression of FABPs in trophoblast cells and the increase in expression of type 1 collagen in ameloblasts. This research belongs to true experimental with a completely randomized design. The sample consisted of 24 female house mice (Mus musculus) which were pregnant and received saltwater fish powder administration made of sardines (Sardinella Fimbriata), pony fish (Leiognathus splendens), and mackerel tuna (Euthynnus affinis). The mice were divided into three concentration groups: Group 1 with 1.07 mg/0.5 ml concentration, Group 2 with 2.14 mg/0.5 ml concentration, and Group 3 as the control group. The samples were stained to see FABP expression and the KLK-4 expression a. Data were analyzed using an independent sample t-test and pathway analysis. The research results showed a significant difference in enamels between the Control Group and Group 1 and Group 2, and there was no significant difference between Group 1 and Group 2. In mother mice that consumed saltwater fish powder, there was an increase in expression of FABPs and a decrease in expression of type 1 collagen.

Original languageEnglish
Pages (from-to)1535-1540
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number4
Publication statusPublished - 2022


  • Ameloblasts
  • Amelogenesis
  • Fabps
  • Saltwater fish powder
  • Type 1 collagen


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