TY - JOUR
T1 - The Effect of Nanoliposome Tumeric Extract Gel (Curcuma longa L.) On TNF Alpha Level of Traumatic Ulcer Healing in The Labial Mucosa Wistar Rats (Rattus Norvegicus)
AU - Fuadiyah, Diena
AU - Purwanto, Bambang
AU - Ratnawati, Retty
AU - Rachmawati, Yuanita Lely
AU - Nugraheni, Raditya
AU - Nurma, Izatannisa
AU - Pndora, Almeta D.
AU - Intan, Aretha M.
AU - Yolanda, Friesca A.
AU - Isnawati, Novi
N1 - Publisher Copyright:
© ISGP 2022.All rights reserved.
PY - 2022/7/5
Y1 - 2022/7/5
N2 - Background: Mucosal ulceration in the oral cavity is very common, especially ulcerations caused by trauma, which are commonly referred to as traumatic ulcers. Based on existing research, turmeric contains active substances in the form of curcumin and flavonoids to accelerate the wound healing process. The wound healing process is a very complex process consisting of 4 phases, namely hemostatic, inflammatory, proliferative, and remodeling phases. Macrophages will also release growth factor TNF alpha which triggers new tissue, after the inflammatory phase. Methods: This study was an experimental study using a randomized post-test only control group design with test animals of Ratus Novergicus. In this study, there were 9 groups, namely the control group, the 0.1% triamcinolone acetonide treatment group, and the turmeric extract nanoliposome gel group, each was given with 3 time series, namely the 3rd, 5th and 7th day. Then IHK preparations were made to see TNF alpha. Results: One way ANOVA test showed differences in TNF Alpha between the control group, the Triamcinolone acetonide, and nanoliposome gel group. TNF alpha shows a deflation amount from day 3, 5 and 7. Nanoliposome group treatment on day 7 had the lowest amount. It can be concluded that the nanoliposome gel of turmeric extract (Curcuma longa L.) has an effect on decreased TNF alpha levels. The decrease of tnf alpha numbers indicates that the inflammatory phase is over and continues to the proliferative and remodeling phase. Conclusion: Based on the results of this study, nanoliposome turmeric extract gel (Curcuma longa L.) has an effect decreased on TNF alpha levels.
AB - Background: Mucosal ulceration in the oral cavity is very common, especially ulcerations caused by trauma, which are commonly referred to as traumatic ulcers. Based on existing research, turmeric contains active substances in the form of curcumin and flavonoids to accelerate the wound healing process. The wound healing process is a very complex process consisting of 4 phases, namely hemostatic, inflammatory, proliferative, and remodeling phases. Macrophages will also release growth factor TNF alpha which triggers new tissue, after the inflammatory phase. Methods: This study was an experimental study using a randomized post-test only control group design with test animals of Ratus Novergicus. In this study, there were 9 groups, namely the control group, the 0.1% triamcinolone acetonide treatment group, and the turmeric extract nanoliposome gel group, each was given with 3 time series, namely the 3rd, 5th and 7th day. Then IHK preparations were made to see TNF alpha. Results: One way ANOVA test showed differences in TNF Alpha between the control group, the Triamcinolone acetonide, and nanoliposome gel group. TNF alpha shows a deflation amount from day 3, 5 and 7. Nanoliposome group treatment on day 7 had the lowest amount. It can be concluded that the nanoliposome gel of turmeric extract (Curcuma longa L.) has an effect on decreased TNF alpha levels. The decrease of tnf alpha numbers indicates that the inflammatory phase is over and continues to the proliferative and remodeling phase. Conclusion: Based on the results of this study, nanoliposome turmeric extract gel (Curcuma longa L.) has an effect decreased on TNF alpha levels.
UR - http://www.scopus.com/inward/record.url?scp=85176462219&partnerID=8YFLogxK
U2 - 10.1051/bioconf/20224906001
DO - 10.1051/bioconf/20224906001
M3 - Conference article
AN - SCOPUS:85176462219
SN - 2273-1709
VL - 49
JO - BIO Web of Conferences
JF - BIO Web of Conferences
M1 - 06001
T2 - 3rd International Symposium on Global Physiology, ISGP 2022
Y2 - 19 January 2022 through 20 January 2022
ER -