THE EFFECT OF MANGOSTEEN PERICARP (GARCINIA MANGOSTANA L.) EXTRACT MUCOADHESIVE GINGIVAL PATCH ON THE MDA LEVELS AND THE NUMBER OF MICRONUCLEI DUE TO PANORAMIC RADIOGRAPHY RADIATION

Deny Saputra, Eha Renwi Astuti, Anindita Daraninggar, Anisah Rachmatul Alam, Febrianti Adi Satria, Muhammad Aulia

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Abstract

The aim of this study is to determine the effect of mangosteen pericarp mucoadhesive gingival patch on the MDA levels and the number of micronuclei in gingival tissues due to panoramic radiography radiation. 35 Rattus norvegicus samples were divided into 7 groups and were given mucoadhesive gingival patches. Then, the rats were exposed to x-ray radiation. The gingival tissues were taken for histopathological examination to determine the micronuclei number and TBARS Test for the MDA levels. There were differences in MDA levels and micronuclei number between rats treated with mangosteen gingival patches and those did not. Application of mangosteen pericarp mucoadhesive patches can reduce the MDA levels and the number of micronuclei in rat’s gingival tissues due to panoramic radiography radiation.

Original languageEnglish
Pages (from-to)4877-4882
Number of pages6
JournalBiochemical and Cellular Archives
Volume20
Issue number2
Publication statusPublished - Oct 2020

Keywords

  • Garcinia mangostana L.
  • Herbal medicine
  • malondialdehyde
  • micronuclei
  • mucoadhesive gingival patch

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