This study aimed to examine the effect of kebar grass extract on the Leydig cells number of mice to exposed 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). These animals were divided into five groups. Twenty five BALB/C mice were used with five groups: Negative Control (C-), Positive Control (C+) with TCDD 7µg/kgBW IP, and treatment groups that treated with TCDD 7µg/kgBW IP and Kebar Grass orally for 53 days were presented T1 0,045mg/gBW/day, T2 0,080mg/gBW/day, and T3 0,135mg/gBW/day. Results showed that TCDD decreased the Leydig cells number, while kebar grass extract was increase the number of Leydig cells exposed by TCCD significantly (p<0,05). But the increase in the number of Leydig cells had not yet reached the normal number of Leydig cells.

Original languageEnglish
Pages (from-to)2287-2291
Number of pages5
JournalInternational Journal of Pharmaceutical Research
Issue number4
Publication statusPublished - 1 Oct 2020


  • Biophytumpetersianum Klotzsch
  • Kebar Grass
  • Leydig cells
  • Mice
  • TCDD


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