TY - JOUR
T1 - The effect of il-6 enhancement due to oral cavity infection on skeletal muscle
AU - Kristanti, Risma Aprianda
AU - Ramadhani, Aulia
AU - Setijanto, R. Darmawan
N1 - Publisher Copyright:
© 2020 EManuscript Technologies. All rights reserved.
PY - 2020
Y1 - 2020
N2 - One of the cytokines that often play a role in the body's response mechanism to infections, inflammation, and various other diseases is Interleukin-6 (IL-6). The role of IL-6 is determined by the signaling mechanism involving various intracellular molecules. Oral infection that can cause an increase in IL-6 level mainly is periodontitis. In periodontitis, the increased level of IL-6 do not only occur locally, but also systemically, in which it affects several tissues, one of which is skeletal muscle. Several studies have proven that the enhancement of IL-6 levels which are caused by oral cavity infections influences the skeletal muscle tissue in both humans and experimental animals. The results of the IL-6 signaling can result in the reduction of muscle mass. The mechanism of IL-6 level enhancement, which results from the host response to oral cavity infections affecting skeletal muscle, is still being discussed and investigated further.
AB - One of the cytokines that often play a role in the body's response mechanism to infections, inflammation, and various other diseases is Interleukin-6 (IL-6). The role of IL-6 is determined by the signaling mechanism involving various intracellular molecules. Oral infection that can cause an increase in IL-6 level mainly is periodontitis. In periodontitis, the increased level of IL-6 do not only occur locally, but also systemically, in which it affects several tissues, one of which is skeletal muscle. Several studies have proven that the enhancement of IL-6 levels which are caused by oral cavity infections influences the skeletal muscle tissue in both humans and experimental animals. The results of the IL-6 signaling can result in the reduction of muscle mass. The mechanism of IL-6 level enhancement, which results from the host response to oral cavity infections affecting skeletal muscle, is still being discussed and investigated further.
KW - Il-6 periodontitis
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85090239435&partnerID=8YFLogxK
U2 - 10.31838/srp.2020.5.81
DO - 10.31838/srp.2020.5.81
M3 - Article
AN - SCOPUS:85090239435
SN - 0975-8453
VL - 11
SP - 597
EP - 602
JO - Systematic Reviews in Pharmacy
JF - Systematic Reviews in Pharmacy
IS - 5
ER -