TY - GEN
T1 - The effect of Graptophyllum pictum (L.) Griff leaf extract on morphometry and calcium levels of ovariectomized mice femur
AU - Rakasiwi, Hilman Lila
AU - Suhargo, Listijani
AU - Sugiharto,
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/7/3
Y1 - 2019/7/3
N2 - Menopause can occur osteoporosis caused by low estrogen. This research was aimed to determine the effect of G. pictum extract on the morphometry and the calcium level of mice femoral bone had been ovariectomized. K1 as a non ovariectomy group was given 0.1 mL of CMC with a dose of 1 g/L, K2 as an control group with 0.1 mL CMC at a dose of 1g/L, K3 as an control group with 0.1 mL of synthetic estrogen at a dose of 0.0104 mg/kgBW, P1 and P2 as the treatment group, 0.1 mL G. pictum extract with a dose of 20 mg/kgBW and 30 mg/kgBW. All of the groups were administrated for 40 days. The results of the highest measurements of bone weight K2 (0.0722 ± 0.008), bone length P2 (1.71 ± 0.047), proximal metaphysical diameter K3 (0.24 ± 0.032), distal metaphysical diameter K2 (0.27 ± 0.010), K3 diaphysis diameter (0.174 ± 0.015), K3 calcium level (97.178 ± 0.830). The administration of G. pictum leaf extract has no effect on bone morphometry but can increase the calcium content of the femur. The optimum dose of G. pictum extract in raising bone calcium levels is 30 mg/kgBW.
AB - Menopause can occur osteoporosis caused by low estrogen. This research was aimed to determine the effect of G. pictum extract on the morphometry and the calcium level of mice femoral bone had been ovariectomized. K1 as a non ovariectomy group was given 0.1 mL of CMC with a dose of 1 g/L, K2 as an control group with 0.1 mL CMC at a dose of 1g/L, K3 as an control group with 0.1 mL of synthetic estrogen at a dose of 0.0104 mg/kgBW, P1 and P2 as the treatment group, 0.1 mL G. pictum extract with a dose of 20 mg/kgBW and 30 mg/kgBW. All of the groups were administrated for 40 days. The results of the highest measurements of bone weight K2 (0.0722 ± 0.008), bone length P2 (1.71 ± 0.047), proximal metaphysical diameter K3 (0.24 ± 0.032), distal metaphysical diameter K2 (0.27 ± 0.010), K3 diaphysis diameter (0.174 ± 0.015), K3 calcium level (97.178 ± 0.830). The administration of G. pictum leaf extract has no effect on bone morphometry but can increase the calcium content of the femur. The optimum dose of G. pictum extract in raising bone calcium levels is 30 mg/kgBW.
UR - http://www.scopus.com/inward/record.url?scp=85068775613&partnerID=8YFLogxK
U2 - 10.1063/1.5115734
DO - 10.1063/1.5115734
M3 - Conference contribution
AN - SCOPUS:85068775613
T3 - AIP Conference Proceedings
BT - International Conference on Biology and Applied Science, ICOBAS 2019
A2 - Romaidi, null
A2 - Wahyudi, Didik
A2 - Daryono, Retno Novvitasari Hery
A2 - Yusnawan, Eriyanto
A2 - Kikuchi, Akira
PB - American Institute of Physics Inc.
T2 - International Conference on Biology and Applied Science 2019, ICOBAS 2019
Y2 - 13 March 2019 through 14 March 2019
ER -