TY - JOUR
T1 - The effect of ginkgo biloba (Egb) extracts on the expression of hsp 90, vegf and bdnf in therattus novergicus with lead (Pb) exposure
AU - Hamdan, Muhammad
AU - Noorhamdani, A. S.
AU - Rahayu, Masruroh
AU - Machfoed, Mohammmad Hasan
N1 - Publisher Copyright:
© 2020 University of Dicle.
PY - 2020
Y1 - 2020
N2 - The rapid industrial growth did regrettably create new problems, especially in a heavy amount of lead (Pb) waste. This may cause intoxication, that give rise to health problems specifically in the nervous system. EGb is believed to have neuroprotective effects. Despite lots of studies, the mechanism of action of EGb on repairing brain cell damage due to exposure to Pb remains unclear. The effect of EGb on neuron proteins related to apoptosis and neuronal cell death due to Pb intoxication remains unknown. To determine the effect of Ginkgo biloba extract on the expression of HSP 90, VEGF and BDNF on Rattus novergicus exposed to Pb. This study was experimental by means of randomized experimental post study design. The study population used was male rats, aged 4-5 months, weighing 140-150 grams. The sample of this study was healthy male rats fulfilling the inclusion criteria and exclusion criteria, that was divided into 4 groups. The variables in this study were independent variables, dependent variables, and controlled variables. After the data were obtained and analyzed, a statistical analysis was performed. Based on the acquired data, the HSP 90 levels among groups differed significantly (p=.004), so did the VEGF (p=.030). Likewise, a significant difference among treatment groups was also recorded on the expression of BDNF (p=.004). EGb can reduce HSP 90 expression in rats exposed to lead. EGb can increase VEGF expression in rats exposed to lead. EGb can increase BDNF expression in rats exposed to lead.
AB - The rapid industrial growth did regrettably create new problems, especially in a heavy amount of lead (Pb) waste. This may cause intoxication, that give rise to health problems specifically in the nervous system. EGb is believed to have neuroprotective effects. Despite lots of studies, the mechanism of action of EGb on repairing brain cell damage due to exposure to Pb remains unclear. The effect of EGb on neuron proteins related to apoptosis and neuronal cell death due to Pb intoxication remains unknown. To determine the effect of Ginkgo biloba extract on the expression of HSP 90, VEGF and BDNF on Rattus novergicus exposed to Pb. This study was experimental by means of randomized experimental post study design. The study population used was male rats, aged 4-5 months, weighing 140-150 grams. The sample of this study was healthy male rats fulfilling the inclusion criteria and exclusion criteria, that was divided into 4 groups. The variables in this study were independent variables, dependent variables, and controlled variables. After the data were obtained and analyzed, a statistical analysis was performed. Based on the acquired data, the HSP 90 levels among groups differed significantly (p=.004), so did the VEGF (p=.030). Likewise, a significant difference among treatment groups was also recorded on the expression of BDNF (p=.004). EGb can reduce HSP 90 expression in rats exposed to lead. EGb can increase VEGF expression in rats exposed to lead. EGb can increase BDNF expression in rats exposed to lead.
KW - BDNF
KW - Hippocampal neuron cell damage to be hsp 90
KW - VEGF
UR - http://www.scopus.com/inward/record.url?scp=85084758200&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85084758200
SN - 1309-100X
VL - 13
SP - 17
EP - 22
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 1
ER -