The effect of free peritoneal patch on bursting pressure in primary gastric suturing with peritonitis conditions (study on New Zealand White rabbits)

Background: perforated peptic ulcer is still a challenge for surgeons and requires a strategy to provide a good outcome. Currently, research on protective biomaterials still has limitations. Free peritoneal patch has growth factors, is antimicrobial, and increases angiogenesis and progenitor properties, which is useful for wound healing. This study examines the healing of primary gastric suturing with peritoneal patches in peritonitis conditions by measuring bursting pressure. Methods: Researchers conducted an experimental study using 30 New Zealand White Rabbits induced by fecal peritonitis. An artificial perforation with a diameter of 1 cm in the gastric corpus was performed, and primary suturing was performed using 5/0 silk thread with 2 simple sutures. In the treatment group, a free peritoneal patch was added. The bursting pressure examination was carried out on the 7^th postoperative day. Results: Changes in the body weight of the rabbits before and after surgery reflecting the nutritional status of the sample did not significantly affect the value of bursting pressure (p>0.05). Meanwhile, the value of bursting pressure in the primary gastric suturing group with a free peritoneal patch was significantly higher than in the primary gastric suturing group without adding a free peritoneal patch (p<0.05). Conclusion: A free peritoneal patch can be used as a biological dressing to prevent leakage in gastric primary suturing in conditions of peritonitis, as shown by higher bursting pressure values.