TY - JOUR
T1 - The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders
T2 - A systematic review and meta-analysis of randomized clinical trials
AU - Mahmudiono, Trias
AU - Jasim, Saade Abdalkareem
AU - Karim, Yasir Salam
AU - Bokov, Dmitry Olegovich
AU - Abdelbasset, Walid Kamal
AU - Akhmedov, Kholmurod S.
AU - Yasin, Ghulam
AU - Thangavelu, Lakshmi
AU - Mustafa, Yasser Fakri
AU - Shoukat, Shehla
AU - Najm, Mazin A.A.
AU - Amraei, Mohammad
N1 - Publisher Copyright:
© 2022 John Wiley & Sons Ltd.
PY - 2022/10
Y1 - 2022/10
N2 - We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.
AB - We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: −3.86 mmHg, 95% CI: −7.59 to −0.13, p =.04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: −1.71 mmHg, 95% CI: −3.67 to 0.26, p =.09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.
KW - blood pressure
KW - flaxseed
KW - hypertension
KW - meta-analysis
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85135019231&partnerID=8YFLogxK
U2 - 10.1002/ptr.7566
DO - 10.1002/ptr.7566
M3 - Review article
C2 - 35859037
AN - SCOPUS:85135019231
SN - 0951-418X
VL - 36
SP - 3766
EP - 3773
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 10
ER -