Family of Cronic Renal Failure (CRF) patients undergoing Hemodialysis experiences anxiety because the family does not have good information about CRF, does not know how to take good care of it, and the family does not have self-awareness and good coping mechanisms. Nurses can provide family psychoeducation therapy, which is a therapy to strengthen coping strategies to reduce the level of patient family anxiety. The purpose of this study was to determine the effect of family psychoeducation therapy on anxiety levels of CRF patients undergoing Hemodialysis. Quasi experimental design pretest-posttest with control group design. The sample size was determined by purposive sampling, a total of 60 respondents with 30 control groups, and 30 treatments. The instrument uses the Zung-Self Rating Anxiety Scale (ZSRAS) questionnaire. Analysis using Wilcoxon Signed Ranks Test and Mann-Whitney U Test. There was no difference in anxiety levels in the control group (p = 0.317). There was a difference in the anxiety level in the treatment group (p = 0,000). There was a difference between the control and treatment groups (p = 0.010). Family psychoeducation therapy can have a positive effect by reducing anxiety in the families of patients with chronic renal failure undergoing Hemodialysis. Nurses can apply psychoeducation therapy to reduce the level of family anxiety of patients with chronic renal failure undergoing Hemodialysis. It is hoped that other researchers can measure the effect of family psychoeducation therapy on optimizing the role and function of the family or the level of family knowledge of CRF patients undergoing Hemodialysis.