The effect of exposure to electric fields on EGFR and PDGFR in glioblastoma cell model: In vitro study

The aim of this study was to determine differences in expression of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR)) in glioblastoma cell cultures in vitro when exposed to electric fields. This work followed a true experimental research design with a post-test only control group design. Glioblastoma cell culture was divided into 2 groups, namely the glioblastoma cell culture group exposed to electric field and those that were not exposed. This tool provided a voltage of 10, 30, and 50 peak to peak Voltage (Vpp) with a frequency of 100 KHz alternating current (AC). Evaluation of EGFR and PDGFR expressions was carried out after exposure. Exposure to a weak electric field with medium frequency for 24, 48, and 72 hours decreased the expression of EGFR and PDGFR in the angiogenesis process of glioblastoma cell cultures in vitro but not significantly. Further research is needed with a larger range of doses and treatment duration.