TY - JOUR
T1 - The Effect of Exercise Intensity on Anthropometric Parameters and Renal Damage in High Fructose-Induced Mice
AU - Sari, Dewi Ratna
AU - Ramadhan, Roy Novri
AU - Agustin, Dini
AU - Munir, Misbakhul
AU - Izzatunnisa, Nabilah
AU - Susanto, Joni
AU - Halim, Shariff
AU - Pranoto, Adi
AU - Rejeki, Purwo Sri
N1 - Publisher Copyright:
© Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF)
PY - 2024
Y1 - 2024
N2 - Excessive fructose intake disrupts carbohydrate and lipid metabolism in the kidney, resulting in kidney injury. Exercise has proven to improve the renal fatty acid metabolism, but the effect of various exercise intensities in preventing renal disorders is still unknown. The purpose of this study is to analyze the effect of various exercise intensities on anthropometric parameters and renal damage in high fructose-induced mice. The subjects were thirty-six male mice (20–30 g), aged 8 weeks were obtained and randomly assigned into 4 groups: HFr-Sed (sedentary), HFr-Ex1 (low-intensity exercise), HFr-Ex2 (moderate-intensity exercise), and HFr-Ex3 (high-intensity exercise). They were fed standard chow and high fructose solution (30%), per-oral, ad libitum for 8 weeks. The exercised groups underwent swimming, with 80% maximum duration/session, 3x/week, for 8 weeks. The result showed that there were significant differences in body weight (p < 0.001), body length (p = 0.001), Lee index (p = 0.020), Body Mass Index (BMI) (p = 0.004), and serum creatinine (SCr) level (p < 0.001). However, the glomerulosclerosis index and interstitial fibrosis degree were not significantly different in all groups. It can be concluded that various intensities of exercise affect the body composition and SCr level, especially moderate-intensity exercise, but do not impact the improvement of the histological kidney in high fructose-induced mice.
AB - Excessive fructose intake disrupts carbohydrate and lipid metabolism in the kidney, resulting in kidney injury. Exercise has proven to improve the renal fatty acid metabolism, but the effect of various exercise intensities in preventing renal disorders is still unknown. The purpose of this study is to analyze the effect of various exercise intensities on anthropometric parameters and renal damage in high fructose-induced mice. The subjects were thirty-six male mice (20–30 g), aged 8 weeks were obtained and randomly assigned into 4 groups: HFr-Sed (sedentary), HFr-Ex1 (low-intensity exercise), HFr-Ex2 (moderate-intensity exercise), and HFr-Ex3 (high-intensity exercise). They were fed standard chow and high fructose solution (30%), per-oral, ad libitum for 8 weeks. The exercised groups underwent swimming, with 80% maximum duration/session, 3x/week, for 8 weeks. The result showed that there were significant differences in body weight (p < 0.001), body length (p = 0.001), Lee index (p = 0.020), Body Mass Index (BMI) (p = 0.004), and serum creatinine (SCr) level (p < 0.001). However, the glomerulosclerosis index and interstitial fibrosis degree were not significantly different in all groups. It can be concluded that various intensities of exercise affect the body composition and SCr level, especially moderate-intensity exercise, but do not impact the improvement of the histological kidney in high fructose-induced mice.
KW - Exercise
KW - healthy lifestyle
KW - obesity
KW - renal histology
UR - http://www.scopus.com/inward/record.url?scp=85180343536&partnerID=8YFLogxK
U2 - 10.47197/RETOS.V51.101189
DO - 10.47197/RETOS.V51.101189
M3 - Article
AN - SCOPUS:85180343536
SN - 1579-1726
VL - 51
SP - 1194
EP - 1209
JO - Retos
JF - Retos
ER -
