TY - JOUR
T1 - The effect of estrogen, progesterone, and its combination on the expression of brain-derived neurotrophic factor medula spinalis in regeneration process of peripheral nerve
AU - Yulianto, Mochamad Rizki
AU - Turchan, Agus
AU - Notobroto, Hari Basuki
N1 - Publisher Copyright:
© 2020, Institute of Medico-Legal Publications. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Background: The presence of modulation factors in the regeneration process of peripheral nerve cells influenced by estrogen and progesterone. Peripheral nerve injury is a fairly common case of trauma. Brain-derived neurotrophic factor (BDNF) is the most active group of neurotrophins in stimulating neurogenesis. Objectives: To proves the effect of estrogen and progesterone on the expression of BDNF on the spinal cord in peripheral nerve regeneration process. Methods: Laboratory experimental study with the completely randomized design. Total transitory nerve ischiadicus was performed on four groups of rats. Each group received hormone therapy according to the group. Hormone therapy is administered every 3 days for 28 days, and on the 29th day is termination, spinal cord sampling, and followed by BDNF expression examination by Immunohistochemistry method. Results: In the control group, BDNF expression of spinal cord neuron cells was 93.0±14.0. In the treatment group, BDNF expression was obtained after estrogen therapy was 77.25±19.19, progesterone was 84.5±20.61, and in a combination of estrogen and progesterone was 77.75±16.54. After statistical tests, no significant differences were found between the treatment groups (p = 0.316). Conclusion: The administration of estrogen, progesterone, or a combination of both did not significantly increase BDNF expression when compared to the control group.
AB - Background: The presence of modulation factors in the regeneration process of peripheral nerve cells influenced by estrogen and progesterone. Peripheral nerve injury is a fairly common case of trauma. Brain-derived neurotrophic factor (BDNF) is the most active group of neurotrophins in stimulating neurogenesis. Objectives: To proves the effect of estrogen and progesterone on the expression of BDNF on the spinal cord in peripheral nerve regeneration process. Methods: Laboratory experimental study with the completely randomized design. Total transitory nerve ischiadicus was performed on four groups of rats. Each group received hormone therapy according to the group. Hormone therapy is administered every 3 days for 28 days, and on the 29th day is termination, spinal cord sampling, and followed by BDNF expression examination by Immunohistochemistry method. Results: In the control group, BDNF expression of spinal cord neuron cells was 93.0±14.0. In the treatment group, BDNF expression was obtained after estrogen therapy was 77.25±19.19, progesterone was 84.5±20.61, and in a combination of estrogen and progesterone was 77.75±16.54. After statistical tests, no significant differences were found between the treatment groups (p = 0.316). Conclusion: The administration of estrogen, progesterone, or a combination of both did not significantly increase BDNF expression when compared to the control group.
KW - Brain-derived neurotrophic factor
KW - Estrogen
KW - Ischiadicus nerve
KW - Neurotrophin
KW - Peripheral nerves
KW - Progesterone
UR - http://www.scopus.com/inward/record.url?scp=85100085067&partnerID=8YFLogxK
U2 - 10.37506/ijfmt.v14i4.12094
DO - 10.37506/ijfmt.v14i4.12094
M3 - Article
AN - SCOPUS:85100085067
SN - 0973-9122
VL - 14
SP - 3150
EP - 3155
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 4
ER -