The effect of different types of swimming intensity on increasing serum bone specific-alkaline phosphatase levels of obese male mice (Mus Musculus)

Obesity can interfere with the bone remodeling process, training is one solution to protect bone density. However, training and its intensity on bone remodeling through the biomarker Bone Specific-Alkaline Phosphatase (BALP) with obesity is still not widely studied so it is still unclear its effectiveness. The experimental study involved 24 mice (Mus musculus) that were induced with 30% fructose once a day for 60 days. Mice were grouped into 4 groups according to the intensity of training, namely the control group without training (K1), low intensity with a load of 3% body weight (K2), moderate intensity with a load of 5% body weight (K3), while high intensity was carried out with a load of 7% body weight for 70% (K4) of the maximum duration. All training sessions with a frequency of 3 times/week, and then a post-test comparison examination of BALP levels was carried out. The average number of BALP levels (ng/mL) in each group post-test, the control group had a result of 15.77±3.10, for the provision of low-intensity training with a value of 13.92±2.23, while for the moderate intensity training group of 13.11±1.67, for the highest increase was in high-intensity training with a value of 21.10±3.70. Based on the Tukey honestly significant difference (HSD) test, the post hoc high-intensity training group was significantly different from other groups (p ≤ 0.05). All types of training intensity analyzed in this study increased BALP levels, especially in the high-intensity training group which had a very significant increase in BALP levels. Therefore, training and its intensity affect bone metabolism increase.