The effect of curcumin in core-shell nanoparticle as therapy in radiotherapy-induced hyposalivation

Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur, Kemal Alif Athallandi, Ayu Anggraini Broto Nagoro, Soesilaningtyas, Rizki Nur Rachman Putra Gofur, Mega Kahdina, Hernalia Martidal Putri

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The gold standard for treating head and neck cancer (HNC) is by radiotherapy. However, the radiation from radiotherapy affecting the salivary glands can cause hyposalivation in patients with incidence of 94-100%. This can negatively affect the function of swallowing, mastication, and vocals, decreasing the patients life quality. Pilocarpin can be used to treat hyposalivation, but it's contradictive to various diseases. Therefore, alternative treatments are needed to treat radiotherapy-induced hyposalivation (RIH). The effect of curcumin in core-shell nanoparticle is the state-of-the-art technology that can be used to treat RIH. Objectives: To explain the effect of curcumin in core-shell nanoparticles as RIH therapy. Discussion: Routinely, HNC patients receive radiotherapy at a dose of 50-70 Gy, which is usually used to destroy malignant cells, but oftenly causes chronic hyposalivation. Decreased salivary levels after radiotherapy often occur in the initial period up to 3 months after radiotherapy. It occurred due to defects in major salivary glands caused by radiotherapy. Curcumin is proven to have an anti-inflammatory effects by inhibiting nuclear factor-kappaB (NF-kB that can trigger excessive tissue damage. This natural ingredients has low oral bioavailability that requires core-shell nanoparticles which can increase the effectiveness of biodistribution and can avoid phagocytosis process to reduce effects of RIH. Conclusion: The effect of curcumin in core-shell nanoparticles has potential as RIH therapy.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalSystematic Reviews in Pharmacy
Volume11
Issue number10
DOIs
Publication statusPublished - 2020

Keywords

  • Core-shell nanoparticle
  • Curcumin
  • Radiotherapy-induced hyposalivation

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