TY - JOUR
T1 - The effect of cigarette smoke exposure due to placental apoptosis and gestation outcomes at gestation disorders mechanism in white rat (Rattus norvegicus)
AU - Sumarsono, Portia
AU - Dhamayanti, Yeni
AU - Hendarti, Gracia Angelina
AU - Widjiati,
AU - Luqman, Epy Muhammad
N1 - Publisher Copyright:
© 2020, Advanced Scientific Research. All rights reserved.
PY - 2020
Y1 - 2020
N2 - The aims of this research to find out the increased incidence of placental apoptosis, abnormal gestation outcomes, and to prove the emergence congenital defects in white rats were exposed to cigarette smoke during gestation. Female white rat (Rattus norvegicus) weighing between 200 and 250 g were used and superovulation used PMSG with a dosage of 10 IU/rat and HCG 10 IU/rat. Female rat were mated, the gestation was indicated by the visible mating plug covering the vulva and then the day was considered the first day of gestation. The animals of the smoking group were exposed to the smoke of five cigarettes per day, from the 6th to the 17th day of pregnancy. The conclusion of this research was the exposure of cigarette smoke can increase the occurence of placental apoptosis on the gestation disorder mechanism on white rat also proved that can cause external congenital disorder on white rat such as body weight loss, foetus body length loss, increasing occurrence of abortus.
AB - The aims of this research to find out the increased incidence of placental apoptosis, abnormal gestation outcomes, and to prove the emergence congenital defects in white rats were exposed to cigarette smoke during gestation. Female white rat (Rattus norvegicus) weighing between 200 and 250 g were used and superovulation used PMSG with a dosage of 10 IU/rat and HCG 10 IU/rat. Female rat were mated, the gestation was indicated by the visible mating plug covering the vulva and then the day was considered the first day of gestation. The animals of the smoking group were exposed to the smoke of five cigarettes per day, from the 6th to the 17th day of pregnancy. The conclusion of this research was the exposure of cigarette smoke can increase the occurence of placental apoptosis on the gestation disorder mechanism on white rat also proved that can cause external congenital disorder on white rat such as body weight loss, foetus body length loss, increasing occurrence of abortus.
KW - Cigarette smoke
KW - Congenital disorder
KW - Placental apoptosis
UR - http://www.scopus.com/inward/record.url?scp=85089309729&partnerID=8YFLogxK
U2 - 10.31838/ijpr/2020.SP1.114
DO - 10.31838/ijpr/2020.SP1.114
M3 - Article
AN - SCOPUS:85089309729
SN - 0975-2366
VL - 12
SP - 731
EP - 735
JO - International Journal of Pharmaceutical Research
JF - International Journal of Pharmaceutical Research
ER -