The effect of Binahong Gel (Anredera cordifolia (Ten.) Steenis) in accelerating the escalation expression of HIF-1α and FGF-2

Tooth extraction is one of treatment acts which is done by dentists in clinics, hospital, and even private practices. One thing that is needed to be observed after the treatment is the speed of wound recovery process post the tooth extraction. Binahong is commonly used as medicinal treatments in Asia, some of them to heal wounds, but there had never been research of the use of Binahong leaf in wound recovery after tooth extraction. The aim of this study was to investigate the effect of Binahong Gel in accelerating the expression of HIF-1a and FGF-2 post tooth extraction on Wistar Rats. This study was used post test only control group design. 48 male Wistar Rats weight between 150-200 grams, 3 months of age are being used. Tooth extraction is being done on lower left incisor. The 48 rats are divided into four groups. The data were analyzed statistically using One-Way ANOVA and LSD_0.05. The result of every tested group showed p>0.05, therefore all the data had a normal distribution. Therefore, a One-Way Anova test with 5% significant rate was done and continued by LSD test to find a significant difference in each groups. Examination showed there was significant difference in expression of HIF-1a and FGF-2 between Binahong gel and two other groups (p<0.05). The application of Binahong gel can accelerate the expression of HIF-1α and FGF-2 post tooth extraction on Wistar Rats.