The Effect Of Administration Of Mangosteen Peel Extract On Reducing Blood Glucose Levels In Experimental Animals Induced Hyperglycemia

Diabetes Mellitus (DM) is a major health problem worldwide. DM with poor control of blood glucose levels can eventually cause pancreatic cell disorders, including a decrease in cell mass and function. Mangosteen rind contains xanthone compounds that can be used to protect and reduce cell damage, especially those caused by free radicals. This study aimed to analyze the effect of mangosteen peel on decreasing blood glucose in a streptozotocin-induced diabetes mellitus model. The research carried out is experimental in the laboratory. The research design used was Randomized Post Test Only Control Group Design. Samples were 24 male Wistar rats. Rats were grouped into 6 groups, namely negative control group, positive control STZ, positive control STZ and metformin, mangosteen peel extract at a dose of 200 mg/kg body weight (P1), a dose of 400 mg/kg body weight (P2), and a dose of 600 mg/kg body weight (P3). Administration of therapy for 14 days orally. The results of the treatment group with a dose of 600mg/kgbw mangosteen rind extract had the lowest fasting blood glucose level of 81 mg/dL, the P2 group at a dose of 400mg/kgbw had a higher fasting blood glucose level of 135 mg/dL, blood glucose levels 136 mg/dL at the P1 dose of treatment 200mg/kgbw. Based on the test using the general linear Manova model, a significance value was obtained, namely p = 0.000 (p <0.05) there was a difference in the average fasting blood sugar level of each group after being treated with mangosteen peel extract. The conclusion of the dose of mangosteen rind extract had an effect on decreasing blood glucose levels with an effective dose of 600 mg/kgbw. This research can provide information to the public about the benefits of mangosteen peel can be developed as an alternative treatment in humans caused by oxidative stress.