TY - JOUR
T1 - The effect of administering salted fish extract as a model of pregnancy hypertension in mus musculus balb-c strain through blood pressure and urinary protein measurements
AU - Anggraeni, Novi
AU - Sulistyono, Agus
AU - Prabowo, Gwenny Ichsan
AU - Aditiawarman, Aditiawarman
N1 - Publisher Copyright:
© 2024 by SPC (Sami Publishing Company).
PY - 2024/12
Y1 - 2024/12
N2 - Globally, hypertension complicates approximately 6-8% of all pregnancies. Hypertension is a risk factor for the occurrence of preeclampsia are 1.591 times more likely to experience preeclampsia compared to those without a history of hypertension. Pregnant women are at risk of developing hypertension if there is a high concentration of salt (NaCl) in their blood, leading to an increase in plasma sodium levels, also known as hypernatremia, which causes the blood plasma to become hypertonic. This study aims to demonstrate the effects of salted fish extract administration as a model of pregnancy hypertension in Balb-C strain Mus musculus mice through blood pressure and urine protein measurements. This study utilized a true experimental design with a post-test only with a control group design. The experimental subjects were pregnant female Mus Musculus Balb-C mice at a gestational age of 1 day. Data analysis was conducted using the non-parametric Kruskal-Wallis test with SPSS 22 software. There were significant differences observed between the negative control group, positive control group (Anti QA-2), groups given salted fish extract with NaCl content of 17.5 mg, 52.6 mg, and 87.8 mg, and the NaCl dose of 52.6 mg, in terms of systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and urine protein levels. The administration of salted fish extract as a model of pregnancy hypertension has an impact on blood pressure and urine protein levels.
AB - Globally, hypertension complicates approximately 6-8% of all pregnancies. Hypertension is a risk factor for the occurrence of preeclampsia are 1.591 times more likely to experience preeclampsia compared to those without a history of hypertension. Pregnant women are at risk of developing hypertension if there is a high concentration of salt (NaCl) in their blood, leading to an increase in plasma sodium levels, also known as hypernatremia, which causes the blood plasma to become hypertonic. This study aims to demonstrate the effects of salted fish extract administration as a model of pregnancy hypertension in Balb-C strain Mus musculus mice through blood pressure and urine protein measurements. This study utilized a true experimental design with a post-test only with a control group design. The experimental subjects were pregnant female Mus Musculus Balb-C mice at a gestational age of 1 day. Data analysis was conducted using the non-parametric Kruskal-Wallis test with SPSS 22 software. There were significant differences observed between the negative control group, positive control group (Anti QA-2), groups given salted fish extract with NaCl content of 17.5 mg, 52.6 mg, and 87.8 mg, and the NaCl dose of 52.6 mg, in terms of systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and urine protein levels. The administration of salted fish extract as a model of pregnancy hypertension has an impact on blood pressure and urine protein levels.
KW - blood pressure
KW - Extract
KW - hypertension
KW - pregnancy
KW - salted fish
KW - urine protein
UR - http://www.scopus.com/inward/record.url?scp=85203295545&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2024.450643.1175
DO - 10.48309/jmpcr.2024.450643.1175
M3 - Article
AN - SCOPUS:85203295545
SN - 2981-0221
VL - 6
SP - 1787
EP - 1796
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 12
ER -