TY - JOUR
T1 - The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA
AU - Cahyani, Febriastuti
AU - Saraswati, Widya
AU - Prasetyo, Eric Priyo
AU - Surboyo, Meircurius Dwi Condro
AU - Riawan, Wibi
AU - Saninggar, Karina Erda
AU - Hariyani, Ninuk
AU - Kusumawardani, Anisa
AU - Soetojo, Adioro
AU - Soetjipto,
N1 - Publisher Copyright:
© 2022. Journal of International Dental and Medical Research. All Rights Reserved.
PY - 2022
Y1 - 2022
N2 - Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.
AB - Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.
KW - Dentin-pulp complex
KW - Hema
KW - Human&health
KW - Pge2
KW - Tlr-4
KW - Α-mangostin
UR - http://www.scopus.com/inward/record.url?scp=85129438894&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85129438894
SN - 1309-100X
VL - 15
SP - 21
EP - 26
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 1
ER -
