The differences of T2RS expression as a sensitivity marker of bitter taste on consumed coffee

Intan Nadzirah, Ari Triwardhani, Hans Lesmana, Aqsa Syuhada Okky, Hendrik Setia Budi, Jenny Sunariani

Research output: Contribution to journalArticlepeer-review


In the body's protective system against poisonous chemicals, which serves as the primary source of warning signals, bitter taste perception plays a role. (Type II Receptor) induced bitter taste T2Rs (in humans) / t2rs (in animals) mainly expressed on the tongue in taste buds. Circumvallate, foliate, and palatal papillae are found in these receptors. Arabica Civet Coffee is one of the coffees that originated in Java, Indonesia, and is renowned for the civet digestive system (Paradoxurushermaphroditus) process. The goal of this research was to establish the differences in the expressions of t2rs as an indicator of bitter taste sensitivity in coffee-given animal studies. 14 rats separated into two parts were included in this experimental study (seven rats per group). Pellets and aquadest without coffee intake were administered to the control group; pellets, aquadest and coffee intake were administered to the treatment group with a normal coffee dosage of 223 mg / ml / day for 30 days. On day 31, the rats were sacrificed and the data examined by the Mann-Whitney Test. Result of this study showed significant different of t2rs expression in the treatment group (1.49 ± 0.08) than (0.03 ± 0.08) in the control group (p<0.05). It can be inferred on the basis of the findings of this analysis that there were higher expressions of t2rs in rats consuming coffee.

Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalSystematic Reviews in Pharmacy
Issue number11
Publication statusPublished - 2020


  • Arabica civet coffee
  • Bitter taste
  • Sensitivity
  • T2Rs expression


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