Abstract

Cancer is a significant global health problem today and responsible for most deaths after cardiovascular diseases. One of the conventional modalities for cancer treatment is chemotherapy. However, it has many side effects and complications. Therefore, the search for novel drug candidates from natural ingredients that are more effective and have minimal side effects is critical. This study is aimed to determine the cytotoxic effect of Allium cepa L. extract on human cervical cancer cells. The cytotoxicity test procedure was performed using MTT assay against HeLa cells. The result revealed that Allium cepa L. ethanolic extract has a weak cytotoxic effect on HeLa cells with IC50 of 900.88 µg/ml. Further research into Allium cepa L. is required to isolate and identify its components and determine their potential as new agents against HeLa cells.

Original languageEnglish
Pages (from-to)4969-4972
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number9
DOIs
Publication statusPublished - Sept 2021

Keywords

  • Cervical cancer
  • Common onion
  • Cytotoxicity assay
  • HeLa cell lines

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