TY - JOUR
T1 - The cytotoxic activity of pine needles ethanolic extract of Pinus merkusii on HeLa cell lines
AU - Proboningrat, Annise
AU - Fadholly, Amaq
AU - Sudjarwo, Sri Agus
AU - Rantam, Fedik Abdul
AU - Achmad, Agung Budianto
N1 - Publisher Copyright:
© The Authors, published by EDP Sciences.
PY - 2021/8/23
Y1 - 2021/8/23
N2 - Several efforts have been made to discover new anticancer agents based on natural ingredients. Meanwhile, previous studies have shown that different Pine genus species exhibit cytotoxic activity against various types of cancer cells. This plant is rich in phenolic compounds, especially procyanidins, flavonoids, and phenolic acids. Therefore, this study aims to investigate the in vitro cytotoxicity of Pinus merkusii needles extract on HeLa cancer cell lines. The cytotoxicity assessment was measured using MTT assay and expressed as IC50 value. The results showed that the ethanolic extract poses a dose and time-dependent cytotoxic activity with an IC50 value of 542.5 µg/ml at 48 hours of incubation. Based on this result, Pinus merkusii needles' ethanolic extract has the potential of a novel candidate for an anticancer agent.
AB - Several efforts have been made to discover new anticancer agents based on natural ingredients. Meanwhile, previous studies have shown that different Pine genus species exhibit cytotoxic activity against various types of cancer cells. This plant is rich in phenolic compounds, especially procyanidins, flavonoids, and phenolic acids. Therefore, this study aims to investigate the in vitro cytotoxicity of Pinus merkusii needles extract on HeLa cancer cell lines. The cytotoxicity assessment was measured using MTT assay and expressed as IC50 value. The results showed that the ethanolic extract poses a dose and time-dependent cytotoxic activity with an IC50 value of 542.5 µg/ml at 48 hours of incubation. Based on this result, Pinus merkusii needles' ethanolic extract has the potential of a novel candidate for an anticancer agent.
UR - http://www.scopus.com/inward/record.url?scp=85159136447&partnerID=8YFLogxK
U2 - 10.1051/bioconf/20213303001
DO - 10.1051/bioconf/20213303001
M3 - Conference article
AN - SCOPUS:85159136447
SN - 2273-1709
VL - 33
JO - BIO Web of Conferences
JF - BIO Web of Conferences
M1 - 03001
T2 - 1st International Conference of Advanced Veterinary Science and Technologies for Sustainable Development, ICAVESS 2021
Y2 - 28 March 2021 through 29 March 2021
ER -
