The cross-talk between the TNF-α and RASSF-hippo signalling pathways

Delvac Oceandy, Bella Amanda, Faisal Yusuf Ashari, Zakiyatul Faizah, M. Aminudin Azis, Nicholas Stafford

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The regulation of cell death through apoptosis is essential to a number of physiological processes. Defective apoptosis regulation is associated with many abnormalities including anomalies in organ development, altered immune response and the development of cancer. Several signalling pathways are known to regulate apoptosis including the Tumour Necrosis Factor-α (TNF-α) and Hippo signalling pathways. In this paper we review the cross-talk between the TNF-α pathway and the Hippo signalling pathway. Several molecules that tightly regulate the Hippo pathway, such as members of the Ras-association domain family member (RASSF) family proteins, interact and modulate some key proteins within the TNF-α pathway. Meanwhile, TNF-α stimulation also aαects the expression and activation of core components of the Hippo pathway. This implies the crucial role of signal integration between these two major pathways in regulating apoptosis.

Original languageEnglish
Article number2346
JournalInternational Journal of Molecular Sciences
Issue number9
Publication statusPublished - 1 May 2019


  • Apoptosis
  • Hippo pathway
  • Signalling pathway
  • TNF-α


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