The correlation between interleukin-1Α and bone destruction on chronic suppurative otitis media with cholesteatoma

Background: Cholesteatoma is a benign lesion in chronic suppurative otitis media having the ability to induce bone around it. Bone damage is caused by osteoclasts and interleukin-1a (IL-1α). Objectives: To analyze the correlation of IL-1α with the degree of bone destruction in cronic suppurative otitis media (CSOM) patients with cholesteatoma treated mastoidectomy surgery Materials and Method: Prospective colectomy tissue collexatoma was taken during mastoidectomy surgery from 20 CSO patients with cholesteatoma. All tissues were processed then IL-1a was quantitatively tested with ELISA using IL-1a specific antibodies. Bone damage rates were categorized into mild, moderate, and severe degrees. Correlation of both variables was analyzed using spearman rank test (p <0.05). Results: The results of IL-1a in cholesteatoma tissue in 20 patients were in the range of 25.01-35.00 pg/ml (30.76 ± 2.99). The degree of bone destruction is mostly in the weight category (65%). The result of analysis of both variables use spearman correlation test (r = 0.625; p = 0.003). Conclusion: There is a strong positive correlation between IL-1 and bone damage rate in CSOM with cholesteatoma.