TY - JOUR
T1 - The comparison toxicity effects of lead and cadmium exposure on hematological parameters and organs of mice
AU - Sugiharto,
AU - Manuhara, Yosephine Sri Wulan
AU - Wibowo, Anjar Tri
AU - Winarni, Dwi
AU - Islamatasya, Ufairanisa
AU - Khasanah, Us Watun Nurul
N1 - Publisher Copyright:
© EM International.
PY - 2020
Y1 - 2020
N2 - The hematopoietic system is very susceptible to lead (Pb) and cadmium (Cd) poisoning, because the metal is bound mostly to erythrocytes and blood plasma. It can cause fragility and damage to blood cells and accumulate in tissues. It leads to cause damage to tissue or organs. The aim of this research was to investigate the comparison toxicity effects of lead and cadmium exposure on hematological parameters (red blood cell count/RBC, hemoglobin concentration/HGB, hematocrit/HCT, mean corpuscular volume/MCV, mean corpuscular hemoglobin concentration/MCHC, mean corpuscular hemoglobin/MCH, platelet count/PLT, differential count percentage of lymphocytes, monocytes, and granulocytes), and weight of organs (liver, spleen, and kidney) in mice. Research was conducted using twenty five male mice, which were grouped into five treatments: P1 = control, P2 = Pb 50 mg/L, P3 = Pb 100 mg/L, P4 = Cd 50 mg/L, and P5 = Cd 100 mg/L. The results showed that to compare the control group, Lead and cadmium exposure are significantly shifted to decrease in RBC, HGB, HCT, percentage of granulocytes, body weight and liver weight; on the contrary increase PLT and percentage of lymphocytes. Lead exposure can increase the value of MCHC and MCH, whereas cadmium exposure actually reduces the value of MCHC and MCH in comparison to the control group.
AB - The hematopoietic system is very susceptible to lead (Pb) and cadmium (Cd) poisoning, because the metal is bound mostly to erythrocytes and blood plasma. It can cause fragility and damage to blood cells and accumulate in tissues. It leads to cause damage to tissue or organs. The aim of this research was to investigate the comparison toxicity effects of lead and cadmium exposure on hematological parameters (red blood cell count/RBC, hemoglobin concentration/HGB, hematocrit/HCT, mean corpuscular volume/MCV, mean corpuscular hemoglobin concentration/MCHC, mean corpuscular hemoglobin/MCH, platelet count/PLT, differential count percentage of lymphocytes, monocytes, and granulocytes), and weight of organs (liver, spleen, and kidney) in mice. Research was conducted using twenty five male mice, which were grouped into five treatments: P1 = control, P2 = Pb 50 mg/L, P3 = Pb 100 mg/L, P4 = Cd 50 mg/L, and P5 = Cd 100 mg/L. The results showed that to compare the control group, Lead and cadmium exposure are significantly shifted to decrease in RBC, HGB, HCT, percentage of granulocytes, body weight and liver weight; on the contrary increase PLT and percentage of lymphocytes. Lead exposure can increase the value of MCHC and MCH, whereas cadmium exposure actually reduces the value of MCHC and MCH in comparison to the control group.
KW - Heavy metal
KW - Hematological parameters
KW - Organs of mice
UR - http://www.scopus.com/inward/record.url?scp=85101237573&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85101237573
SN - 0971-765X
VL - 26
SP - 1842
EP - 1846
JO - Ecology, Environment and Conservation
JF - Ecology, Environment and Conservation
IS - 4
ER -
