The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants

Conny Tanjung; Peter Rzehak; Herawati Sudoyo; Muchtaruddin Mansyur; Zakiudin Munasir; Suzanna Immanuel; Roedi Irawan; Eva Reischl; Hans Demmelmair; Sri Rezeki Hadinegoro; Damayanti Rusli Sjarif; Berthold Koletzko

doi:10.1093/ajcn/nqy166

The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants

Conny Tanjung, Peter Rzehak, Herawati Sudoyo, Muchtaruddin Mansyur, Zakiudin Munasir, Suzanna Immanuel, Roedi Irawan, Eva Reischl, Hans Demmelmair, Sri Rezeki Hadinegoro, Damayanti Rusli Sjarif, Berthold Koletzko

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-PUFA composition in blood and tissues. Objectives: We aimed to investigate the influence of fetal FADS genotypes on LC-PUFA composition in umbilical artery plasma lipids in Indonesian infants. Design: We performed a cross-sectional study to assess for these associations. Results: A total of 12 cord plasma n–6 (ω-6) and n–3 (ω-3) fatty acids were analyzed for associations with 18 FADS gene cluster SNPs from 390 women with single parturition from the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). Fetal FADS genotypes influenced cord plasma LC-PUFA composition, but, in contrast to previous studies from Western populations, the quantitatively predominant SNPs were associated with lower LCPUFA content. Conclusion: To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. The FADS genotype distribution differs markedly between different geographical populations. This trial was registered at clinicaltrials.gov as NCT02401178.

Original language	English
Pages (from-to)	1135-1144
Number of pages	10
Journal	American Journal of Clinical Nutrition
Volume	108
Issue number	5
DOIs	https://doi.org/10.1093/ajcn/nqy166
Publication status	Published - 1 Nov 2018

Keywords

FADS1
FADS2
FADS3
Fetus
Indonesia
LCPUFA composition
Polymorphisms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ajcn/nqy166

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Tanjung, C., Rzehak, P., Sudoyo, H., Mansyur, M., Munasir, Z., Immanuel, S., Irawan, R., Reischl, E., Demmelmair, H., Hadinegoro, S. R., Sjarif, D. R., & Koletzko, B. (2018). The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants. American Journal of Clinical Nutrition, 108(5), 1135-1144. https://doi.org/10.1093/ajcn/nqy166

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title = "The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants",

abstract = "Background: Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-PUFA composition in blood and tissues. Objectives: We aimed to investigate the influence of fetal FADS genotypes on LC-PUFA composition in umbilical artery plasma lipids in Indonesian infants. Design: We performed a cross-sectional study to assess for these associations. Results: A total of 12 cord plasma n–6 (ω-6) and n–3 (ω-3) fatty acids were analyzed for associations with 18 FADS gene cluster SNPs from 390 women with single parturition from the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). Fetal FADS genotypes influenced cord plasma LC-PUFA composition, but, in contrast to previous studies from Western populations, the quantitatively predominant SNPs were associated with lower LCPUFA content. Conclusion: To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. The FADS genotype distribution differs markedly between different geographical populations. This trial was registered at clinicaltrials.gov as NCT02401178.",

keywords = "FADS1, FADS2, FADS3, Fetus, Indonesia, LCPUFA composition, Polymorphisms",

author = "Conny Tanjung and Peter Rzehak and Herawati Sudoyo and Muchtaruddin Mansyur and Zakiudin Munasir and Suzanna Immanuel and Roedi Irawan and Eva Reischl and Hans Demmelmair and Hadinegoro, {Sri Rezeki} and Sjarif, {Damayanti Rusli} and Berthold Koletzko",

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doi = "10.1093/ajcn/nqy166",

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Tanjung, C, Rzehak, P, Sudoyo, H, Mansyur, M, Munasir, Z, Immanuel, S, Irawan, R, Reischl, E, Demmelmair, H, Hadinegoro, SR, Sjarif, DR & Koletzko, B 2018, 'The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants', American Journal of Clinical Nutrition, vol. 108, no. 5, pp. 1135-1144. https://doi.org/10.1093/ajcn/nqy166

TY - JOUR

T1 - The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants

AU - Tanjung, Conny

AU - Rzehak, Peter

AU - Sudoyo, Herawati

AU - Mansyur, Muchtaruddin

AU - Munasir, Zakiudin

AU - Immanuel, Suzanna

AU - Irawan, Roedi

AU - Reischl, Eva

AU - Demmelmair, Hans

AU - Hadinegoro, Sri Rezeki

AU - Sjarif, Damayanti Rusli

AU - Koletzko, Berthold

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-PUFA composition in blood and tissues. Objectives: We aimed to investigate the influence of fetal FADS genotypes on LC-PUFA composition in umbilical artery plasma lipids in Indonesian infants. Design: We performed a cross-sectional study to assess for these associations. Results: A total of 12 cord plasma n–6 (ω-6) and n–3 (ω-3) fatty acids were analyzed for associations with 18 FADS gene cluster SNPs from 390 women with single parturition from the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). Fetal FADS genotypes influenced cord plasma LC-PUFA composition, but, in contrast to previous studies from Western populations, the quantitatively predominant SNPs were associated with lower LCPUFA content. Conclusion: To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. The FADS genotype distribution differs markedly between different geographical populations. This trial was registered at clinicaltrials.gov as NCT02401178.

AB - Background: Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-PUFA composition in blood and tissues. Objectives: We aimed to investigate the influence of fetal FADS genotypes on LC-PUFA composition in umbilical artery plasma lipids in Indonesian infants. Design: We performed a cross-sectional study to assess for these associations. Results: A total of 12 cord plasma n–6 (ω-6) and n–3 (ω-3) fatty acids were analyzed for associations with 18 FADS gene cluster SNPs from 390 women with single parturition from the Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI). Fetal FADS genotypes influenced cord plasma LC-PUFA composition, but, in contrast to previous studies from Western populations, the quantitatively predominant SNPs were associated with lower LCPUFA content. Conclusion: To our knowledge, this study was the first in South East Asia on FADS genotypes and arterial cord blood fatty acids to show an association between fetal LC-PUFA composition and fetal FADS SNPs. The FADS genotype distribution differs markedly between different geographical populations. This trial was registered at clinicaltrials.gov as NCT02401178.

KW - FADS1

KW - FADS2

KW - FADS3

KW - Fetus

KW - Indonesia

KW - LCPUFA composition

KW - Polymorphisms

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U2 - 10.1093/ajcn/nqy166

DO - 10.1093/ajcn/nqy166

M3 - Article

C2 - 30475958

AN - SCOPUS:85057143961

SN - 0002-9165

VL - 108

SP - 1135

EP - 1144

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 5

ER -

The association of fatty acid desaturase gene polymorphisms on long-chain polyunsaturated fatty acid composition in Indonesian infants

Abstract

Keywords

UN SDGs

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