TY - JOUR
T1 - The Association between Plasma miRNA-21 Levels with Overall 1-year Survival Rate of Breast Cancer Patients at Various Stages
AU - Romadhon, Pradana Zaky
AU - Prayoga, Ami Ashariati
AU - Bintoro, Siprianus Ugroseno Yudho
AU - Diansyah, Muhammad Noor
AU - Amrita, Putu Niken
AU - Savitri, Merlyna
AU - Windradi, Choirina
N1 - Funding Information:
We thank to Universitas Airlangga Hospital for supporting the study.
Publisher Copyright:
© 2021, Indonesian Society of Internal Medicine. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion. Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in early stage and 23 in end-stage. We evaluated miRNA-21 values and observed its association with mortality within 1 year. Results: In general, there was a correlation between the increase in miRNA-21 levels and the mortality rate of breast cancer patients (r = 0.651; p <0.05). In the early stages, the increase in miRNA-21 values was not associated with breast cancer mortality (r= 0.25; p=0.218), but in the later stages, we found that the increase in miRNA-21 had a correlation with mortality (r=0.866; p=<0, 05). In advanced stage, high level of miRNA-21 had high asscociation with mortality rate (HR 17,27 95%CI 7,37-40,69). Conclusion: The increase in miRNA-21 values is associated with the 1-year survival of breast cancer patients.
AB - Background: miRNA 21 exhibits an increased expression in breast cancer (BC). However, its relationship with the 1-year survival of breast cancer patients is still disputable and under serious discussion. Methods: Cohort prospective study involving 49 breast cancer patients was done, comprising 26 in early stage and 23 in end-stage. We evaluated miRNA-21 values and observed its association with mortality within 1 year. Results: In general, there was a correlation between the increase in miRNA-21 levels and the mortality rate of breast cancer patients (r = 0.651; p <0.05). In the early stages, the increase in miRNA-21 values was not associated with breast cancer mortality (r= 0.25; p=0.218), but in the later stages, we found that the increase in miRNA-21 had a correlation with mortality (r=0.866; p=<0, 05). In advanced stage, high level of miRNA-21 had high asscociation with mortality rate (HR 17,27 95%CI 7,37-40,69). Conclusion: The increase in miRNA-21 values is associated with the 1-year survival of breast cancer patients.
KW - breast cancer
KW - health
KW - miRNA-21
KW - mortality rate
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=85123567887&partnerID=8YFLogxK
M3 - Article
C2 - 35027490
AN - SCOPUS:85123567887
SN - 0125-9326
VL - 53
SP - 432
EP - 441
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 4
ER -
