The Antioxidant Activity of Pinus merkusii Ethanol Extract as Hepatoprotector in Mice

A. Herdiansyah, Rimayanti, S. A. Sudjarwo

Research output: Contribution to journalArticlepeer-review

Abstract

This study was carried out to investigate the activity of the extract of Pinus merkusii in protecting against lead acetate-induced hepatotoxicity. Mice were given Pinus merkusii 200 mg, 400 mg, and 800 mg/kg BW orally once in a day for 40 days, and on the 5thday, were given lead acetate 30 mg/kg BW one hour after Pinus merkusii extract administration.Pinus merkusiiextracts significantly decreased the aspartate transaminase (AST), alanine transaminase (ALT), Malondialdehyde (MDA) levels and protected liver cell damage in lead acetate induced-hepatocyte. Pinus merkusii extract is a potent antioxidant and provide a promising hepatoprotective effect against lead acetateinduced hepatotoxicity.

Original languageEnglish
Pages (from-to)60-62
Number of pages3
JournalIndian Veterinary Journal
Volume96
Issue number10
Publication statusPublished - 2019

Keywords

  • Hepatotoxicity
  • Lead acetate
  • MDA
  • Pinus merkusii extracts

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