Abstract
This study was carried out to investigate the activity of the extract of Pinus merkusii in protecting against lead acetate-induced hepatotoxicity. Mice were given Pinus merkusii 200 mg, 400 mg, and 800 mg/kg BW orally once in a day for 40 days, and on the 5thday, were given lead acetate 30 mg/kg BW one hour after Pinus merkusii extract administration.Pinus merkusiiextracts significantly decreased the aspartate transaminase (AST), alanine transaminase (ALT), Malondialdehyde (MDA) levels and protected liver cell damage in lead acetate induced-hepatocyte. Pinus merkusii extract is a potent antioxidant and provide a promising hepatoprotective effect against lead acetateinduced hepatotoxicity.
Original language | English |
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Pages (from-to) | 60-62 |
Number of pages | 3 |
Journal | Indian Veterinary Journal |
Volume | 96 |
Issue number | 10 |
Publication status | Published - 2019 |
Keywords
- Hepatotoxicity
- Lead acetate
- MDA
- Pinus merkusii extracts