This study was carried out to investigate the activity of the extract of Pinus merkusii in protecting against lead acetate-induced hepatotoxicity. Mice were given Pinus merkusii 200 mg, 400 mg, and 800 mg/kg BW orally once in a day for 40 days, and on the 5thday, were given lead acetate 30 mg/kg BW one hour after Pinus merkusii extract administration.Pinus merkusiiextracts significantly decreased the aspartate transaminase (AST), alanine transaminase (ALT), Malondialdehyde (MDA) levels and protected liver cell damage in lead acetate induced-hepatocyte. Pinus merkusii extract is a potent antioxidant and provide a promising hepatoprotective effect against lead acetateinduced hepatotoxicity.
|Number of pages||3|
|Journal||Indian Veterinary Journal|
|Publication status||Published - 2019|
- Lead acetate
- Pinus merkusii extracts