TY - JOUR
T1 - The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro
AU - Pujiyanto, Mahendra
AU - Afililla, Zhaza
AU - Maslachah, Lilik
AU - Widiyatno, Thomas Valentinus
AU - Koerniawan, Mochamad Donny
AU - Suyono, Eko Agus
AU - Budiman, Arief
AU - Siregar, Ulfah Juniarti
AU - Suwanti, Lucia Tri
N1 - Publisher Copyright:
© 2022 Faculty of Fisheries and Marine Universitas Airlangga.
PY - 2022/11
Y1 - 2022/11
N2 - Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/ mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.
AB - Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/ mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.
KW - Anti-Malaria Drug
KW - Infectious Disease
KW - Malaria
KW - Tropical Disease
UR - http://www.scopus.com/inward/record.url?scp=85137035593&partnerID=8YFLogxK
U2 - 10.20473/jipk.v14i2.34766
DO - 10.20473/jipk.v14i2.34766
M3 - Article
AN - SCOPUS:85137035593
SN - 2085-5842
VL - 14
SP - 396
EP - 403
JO - Jurnal Ilmiah Perikanan dan Kelautan
JF - Jurnal Ilmiah Perikanan dan Kelautan
IS - 2
ER -
