The Activity of Mixed Microalgae Polysaccharides from Indonesia as Anti-Malaria in Vitro

Mahendra Pujiyanto, Zhaza Afililla, Lilik Maslachah, Thomas Valentinus Widiyatno, Mochamad Donny Koerniawan, Eko Agus Suyono, Arief Budiman, Ulfah Juniarti Siregar, Lucia Tri Suwanti

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium that categorized as deadliest diseases in the world. Artemisinin and its derivatives are still recommended drugs for malaria therapy, however, there have been indications that Plasmodium parasites are resistant to this drug. Therefore, a study on polysaccharides from microalgae may be a potential as bioactive compound for anti-malaria. The aim of this study was to determine the effectiveness of the mixed microalgae polysaccharides as anti-malarial in vitro. Polysaccharides were extracted from three microalgae Spirulina sp., mixed microalgae Glagah and mixed microalgae East Java using the alkaline extraction method. The anti-malarial activity test refers to the concentration of polysaccharides used in calculating the IC50 value by probit analysis. The concentration of polysaccharides of the three microalgae used were 0; 0.01; 0.01, 1, 10 and 100 µg/mL. The results showed that the IC50 values of polysaccharides of Glagah, Spirulina sp. and East Java microalgae were 3.18 µg/mL, 5.43µg/ mL, and 9.87 µg/mL, respectively. In Conclusion, polysaccharides of Indonesian mixed microalgae can be promoted as anti-malarial.

Original languageEnglish
Pages (from-to)396-403
Number of pages8
JournalJurnal Ilmiah Perikanan dan Kelautan
Issue number2
Publication statusPublished - Nov 2022


  • Anti-Malaria Drug
  • Infectious Disease
  • Malaria
  • Tropical Disease


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