TY - JOUR
T1 - The α-smooth muscle actin (α-SMA) and collagen type III expression of Platelet Rich Fibrin (PRF) membrane in conjunctival wound healing
T2 - a literature review
AU - Wiratama, Agung Bhakti
AU - Prastyani, Reni
AU - Wahyuni, Indri
AU - Valentinus, Thomas
AU - Notobroto, Hari Basuki
N1 - Publisher Copyright:
© 2023, Sanglah General Hospital. All rights reserved.
PY - 2023/12
Y1 - 2023/12
N2 - The platelet-rich fibrin (PRF) membrane represents a new reconstructive material employed in ocular surface procedures. Platelet-rich fibrin (PRF) offers several notable benefits, including its potential to mitigate inflammation, its abundance of growth factors, and its capacity to serve as a transient framework for fibroblast migration. Nevertheless, despite the numerous benefits it offers, PRF is not extensively utilized in comparison to alternative methods like conjunctival autograft. The utilization of conjunctival autograft has been a longstanding approach in ocular surface reconstruction methodologies; however, it is not without its inherent limitations. Therefore, the utilization of the PRF membrane technique presents a viable solution for addressing this particular scenario. This literature review aims to present a comprehensive analysis of the role of PRF in the regulation of inflammation and its potential to facilitate the healing of conjunctival wounds. This review is expected to stimulate further experimental investigations into the influence of α-SMA and collagen type III expression on the efficacy of PRF membranes in promoting conjunctival wound healing.
AB - The platelet-rich fibrin (PRF) membrane represents a new reconstructive material employed in ocular surface procedures. Platelet-rich fibrin (PRF) offers several notable benefits, including its potential to mitigate inflammation, its abundance of growth factors, and its capacity to serve as a transient framework for fibroblast migration. Nevertheless, despite the numerous benefits it offers, PRF is not extensively utilized in comparison to alternative methods like conjunctival autograft. The utilization of conjunctival autograft has been a longstanding approach in ocular surface reconstruction methodologies; however, it is not without its inherent limitations. Therefore, the utilization of the PRF membrane technique presents a viable solution for addressing this particular scenario. This literature review aims to present a comprehensive analysis of the role of PRF in the regulation of inflammation and its potential to facilitate the healing of conjunctival wounds. This review is expected to stimulate further experimental investigations into the influence of α-SMA and collagen type III expression on the efficacy of PRF membranes in promoting conjunctival wound healing.
KW - collagen type III
KW - conjunctiva wound healing
KW - s: Platelet-rich fibrin membrane
KW - α-SMA
UR - http://www.scopus.com/inward/record.url?scp=85176933982&partnerID=8YFLogxK
U2 - 10.15562/bmj.v12i3.4746
DO - 10.15562/bmj.v12i3.4746
M3 - Review article
AN - SCOPUS:85176933982
SN - 2089-1180
VL - 12
SP - 2538
EP - 2547
JO - Bali Medical Journal
JF - Bali Medical Journal
IS - 3
ER -