Targeted Reduction of Lipid Peroxidation in Parotid Gland Cell Membranes Due to Fractionated Dose of X-Ray Radiotherapy by Bioactive Compounds of Blue-Green Algae

This study aims to identify the bioactive compounds contained in blue-green algae (Spirulina platensis), determine the malondialdehyde levels between groups induced by single dose X-ray radiotherapy (single fractionation of 10 Gy) and fractionation dose, and determine the ability of these active compounds to repair the lipid membrane damage of the fractionated dose irradiated group. Thirty-six male Rattus norvegicus were divided into six groups: K0 (control group), K1 (single dose irradiated group), K2 (fractionated dose irradiated group), P1 (group irradiated with fractionated dose and given 300 mg/kg BW blue-green algae), P2 (group irradiated at a fractionated dose and given 600 mg/kg BW blue-green algae), and P3 (group irradiated at a fractionated dose and given 900 mg/kg BW blue-green algae). The results showed that the group irradiated with a single dose showed a higher increase in malondialdehyde levels than the group induced by fractionated dose radiotherapy. The bioactive content of blue-green algae can reduce malondialdehyde levels.