Systematic Review and Meta-Analysis of Effects of Nurse-Led Intervention for People With Dementia

Kuei Hsiang Huang, Ita Daryanti Saragih, Ira Suarilah, Nguyen Thi Son, Bih O. Lee

Research output: Contribution to journalArticlepeer-review


Background Nurses' primary role in clinical settings for persons living with dementia is to lessen the strain of dementia on daily life, monitor comorbidities, and manage medications. However, no comprehensive literature review has investigated the effectiveness of nurse-led interventions for persons living with dementia. Objective The purpose of this study was to evaluate randomized controlled trials on the efficacy of nurse-led dementia interventions and provide an extended range of outcomes related to cognitive function, depression, and quality of life. Methods A comprehensive literature search of six databases was conducted from database inception to August 10, 2022. Methodologies were evaluated, followed by a pooled analysis using random effects models to explain the effects of nurse-led dementia interventions on patients. Results Nurse-led interventions were more effective than standard care in alleviating depression and improving quality of life. However, they did not enhance cognitive performance. Discussion Nurse-led interventions for dementia alleviate depression and improve quality of life. However, because of lack of randomized controlled trials, the analysis found less effectiveness in improving cognitive function. Therefore, further trials are needed to corroborate these findings.

Original languageEnglish
Pages (from-to)430-438
Number of pages9
JournalNursing Research
Issue number6
Publication statusPublished - 1 Nov 2023


  • dementia
  • meta-analysis
  • nurse-led interventions


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