TY - JOUR
T1 - Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen
T2 - Drug release kinetic modeling and cytotoxicity study
AU - Neolaka, Yantus A.B.
AU - Lawa, Yosep
AU - Riwu, Magdarita
AU - Darmokoesoemo, Handoko
AU - Setyawati, Harsasi
AU - Naat, Johnson
AU - Ayu Widyaningrum, Bernadeta
AU - Osagie Aigbe, Uyiosa
AU - Eghonghon Ukhurebor, Kingsley
AU - Birundu Onyancha, Robert
AU - Kusuma, Heri Septya
N1 - Funding Information:
The Ministry of Education, Culture, Research and Technology of the Republic of Indonesia is gratefully acknowledged for the Basic Research Grant No. B/1176/E3/RA.00/2020 was awarded to the first author. For their contributions to this research, the first author additionally acknowledges Maria F. Bui, Esmiralda C. Wila, Mutiah A. Fahirah, and Titah Aldila Budiastanti.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/1
Y1 - 2022/1
N2 - Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future.
AB - Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future.
KW - Drug Carrier
KW - Drug Safety
KW - Ibuprofen
KW - Mordenite
KW - Zn(II)
UR - http://www.scopus.com/inward/record.url?scp=85146199726&partnerID=8YFLogxK
U2 - 10.1016/j.rechem.2022.100578
DO - 10.1016/j.rechem.2022.100578
M3 - Article
AN - SCOPUS:85146199726
SN - 2211-7156
VL - 4
JO - Results in Chemistry
JF - Results in Chemistry
M1 - 100578
ER -