Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study

Yantus A.B. Neolaka, Yosep Lawa, Magdarita Riwu, Handoko Darmokoesoemo, Harsasi Setyawati, Johnson Naat, Bernadeta Ayu Widyaningrum, Uyiosa Osagie Aigbe, Kingsley Eghonghon Ukhurebor, Robert Birundu Onyancha, Heri Septya Kusuma

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future.

Original languageEnglish
Article number100578
JournalResults in Chemistry
Volume4
DOIs
Publication statusPublished - Jan 2022

Keywords

  • Drug Carrier
  • Drug Safety
  • Ibuprofen
  • Mordenite
  • Zn(II)

Fingerprint

Dive into the research topics of 'Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study'. Together they form a unique fingerprint.

Cite this