TY - JOUR
T1 - Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen
T2 - Drug release kinetic modeling and cytotoxicity study
AU - Neolaka, Yantus A.B.
AU - Lawa, Yosep
AU - Riwu, Magdarita
AU - Darmokoesoemo, Handoko
AU - Setyawati, Harsasi
AU - Naat, Johnson
AU - Ayu Widyaningrum, Bernadeta
AU - Osagie Aigbe, Uyiosa
AU - Eghonghon Ukhurebor, Kingsley
AU - Birundu Onyancha, Robert
AU - Kusuma, Heri Septya
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/1
Y1 - 2022/1
N2 - Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future.
AB - Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare Zn(II)-ZMT material. XRD, FTIR, and FESEM-EDS were used to characterize the physico-chemical characteristics of all materials. The performance of Zn(II)-ZMT as a drug delivery agent for ibuprofen was also evaluated using drug loading-release, zeta potential measurement, and cytotoxicity testing. Six kinetic models (including the zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, and Korsmeyer-Peppas models) were utilized to simulate the drug release process. Meanwhile, a microtetrazolium (MTT) assay was used to analyze the material's cytotoxicity. The Zn(II)-ZMT material has a drug loading content (DLC) of 90.37 % and an efficiency entrapment content (EEC) of 54.22 %, according to drug loading. The drug releases kinetic modeling of Ibuprofen from Zn(II)-ZMT followed the Hixson-Crowell model. This material exhibits good biocompatibility based on a cytotoxicity test using the MTT assay. Ibu@Zn(II)-ZMT has a zeta potential of − 61.55 mV ± 0.1 mV. These findings suggest that the material in the dispersion system has a high degree of stability, indicating that it will not flocculate or coagulate in the body. Furthermore, Zn(II)-ZMT is an inorganic substance that has the potential to be employed as a medication delivery material in the future.
KW - Drug Carrier
KW - Drug Safety
KW - Ibuprofen
KW - Mordenite
KW - Zn(II)
UR - http://www.scopus.com/inward/record.url?scp=85146199726&partnerID=8YFLogxK
U2 - 10.1016/j.rechem.2022.100578
DO - 10.1016/j.rechem.2022.100578
M3 - Article
AN - SCOPUS:85146199726
SN - 2211-7156
VL - 4
JO - Results in Chemistry
JF - Results in Chemistry
M1 - 100578
ER -