Synthesis of some chalcone derivatives, in vitro and in silico toxicity evaluation

A. N. Kristanti, H. Suwito, N. S. Aminah, K. U. Haq, H. D. Hardiyanti, H. Anggraeni, N. Faiza, R. S. Anto, S. Muharromah

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the best method. The objevtives of this study were to synthesize some chalcone derivatives using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´-hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.

Original languageEnglish
Pages (from-to)654-662
Number of pages9
JournalRasayan Journal of Chemistry
Issue number1
Publication statusPublished - 1 Jan 2020


  • 2-Hydroxychalcone Derivatives
  • Apoptosis
  • Claisen-Schmidt Condensation
  • HeLa Cell
  • MDM2 Protein


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