8 Citations (Scopus)


Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the best method. The objevtives of this study were to synthesize some chalcone derivatives using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´-hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC50, but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.

Original languageEnglish
Pages (from-to)654-662
Number of pages9
JournalRasayan Journal of Chemistry
Issue number1
Publication statusPublished - 1 Jan 2020


  • 2-Hydroxychalcone Derivatives
  • Apoptosis
  • Claisen-Schmidt Condensation
  • HeLa Cell
  • MDM2 Protein


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