Synthesis of Hydroxyapatite Based on Nano Coral Using precipitation Method for Bone Substitution

Siswanto, Dyah Hikmawati, N. Benecdita, Siti Nurmala

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2 Citations (Scopus)


The synthesis of hydroxyapatite based nano coral by precipitation method already has been done. This method is chosen because it does not need to use organic solvents, simple, cheap and effectively. The selection of coral as a base material because the material has a fairly high calcium content. Moreover, this element is a major component of bone and availability in Indonesia is abundant. By using 3D HEM (High Energy Milling) for 20 hours milling can be formed 64.93 nm coral powder. The treatment of calcination of CaCO3 at 900°C for 3 hours on this coral powder produced CaO. Dissolution of this material in aquades can be formed Ca (OH)2 and this study uses the concentration of the solution as research variables, namely (0.6, 0.85, 1.1, 1.35, 1.6) M. Hydroxyapatite can be formed by reacting calcium hydroxide solution Ca(OH)2 with phosphoric acid (H3PO4) in a stirrer and then precipitated. Observation of the precipitate formed the occurrence of hydroxyapatite and β-TCP (β-Tricalcium Phosphate) phases. The calcium hydroxide concentration that produces the most optimal hydroxyapatite is at a concentration of 0.85 M resulting in a hydroxyapatite phase of 95.3% and a β-tricalcium phosphate phase Ca3(PO4)2 of 4.7%. The ratio Ca/P in this concentration is 1, 66, shows that almost same with an ideal hydroxyapatite 1, 67, and this hydroxyapatite is a good candidate for bone substitution.

Original languageEnglish
Article number012015
JournalJournal of Physics: Conference Series
Issue number1
Publication statusPublished - 27 Jan 2020
EventInternational Symposium on Nanoscience and Nanotechnology in Life Sciences 2017, ISNNLS 2017 - Surabaya, Indonesia
Duration: 28 Nov 201729 Nov 2017


  • Coral
  • Hidroxyapatite
  • Precipitation


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