TY - GEN
T1 - Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea- p -toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA)
AU - Haq, Kautsar Ul
AU - Dewi, Septi Rosiana
AU - Cicilianingrum, Sherly Dwi
AU - Anggraini, Amalia Muti
AU - Dahana, Zella Dwipuspita
AU - Sari, Indrianti Yunita
AU - Renjanawati, Rina Dewi
AU - Wardana, Januardi
AU - Gunawan, Fandi
AU - Muschafi, Nuzilatul
AU - Rosyidah, Nisa'Ur
AU - Suwito, Hery
N1 - Funding Information:
The authors acknowledge The Ministry of Research, Technology and Higher Education through PDUPT research scheme 2019, contract No 4/E1/Kp.PTNBH/2019.
Publisher Copyright:
© 2020 Author(s).
PY - 2020/6/2
Y1 - 2020/6/2
N2 - Derivatives of 5-benzylidenehydantion are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. The preparation methods of 5-benzylidenehydantoin and 5- benzylidenecreatinine derivatives obtained from the reaction between aromatic aldehydes with hydantoin or creatinine using Knoevenagel condensation are discussed. Performing the reactions, we used mixed catalysts system that were Urea- p-Toluene sulfonic acid (Urea-PTSA) and Guanidine hydrochloride-triethylamine (GnHCl-TEA) in polyethylene glycol as solvent. The reaction conditions were suitable for the reaction of aromatic aldehydes attaching electron donating substituent, as well as electron withdrawing substituents. Catalyst system of Urea-PTSA furnished best yield for rich electron aldehydes, while catalyst system of GnHCl-TEA were suitable for poor electron aldehydes and heteroaromatic aldehydes.
AB - Derivatives of 5-benzylidenehydantion are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. The preparation methods of 5-benzylidenehydantoin and 5- benzylidenecreatinine derivatives obtained from the reaction between aromatic aldehydes with hydantoin or creatinine using Knoevenagel condensation are discussed. Performing the reactions, we used mixed catalysts system that were Urea- p-Toluene sulfonic acid (Urea-PTSA) and Guanidine hydrochloride-triethylamine (GnHCl-TEA) in polyethylene glycol as solvent. The reaction conditions were suitable for the reaction of aromatic aldehydes attaching electron donating substituent, as well as electron withdrawing substituents. Catalyst system of Urea-PTSA furnished best yield for rich electron aldehydes, while catalyst system of GnHCl-TEA were suitable for poor electron aldehydes and heteroaromatic aldehydes.
UR - http://www.scopus.com/inward/record.url?scp=85086340913&partnerID=8YFLogxK
U2 - 10.1063/5.0005378
DO - 10.1063/5.0005378
M3 - Conference contribution
AN - SCOPUS:85086340913
T3 - AIP Conference Proceedings
BT - 14th Joint Conference on Chemistry 2019
A2 - Rahmawati, Fitria
A2 - Saraswati, Teguh Endah
A2 - Nugrahaningtyas, Khoirina Dwi
A2 - Marliyana, Soerya Dewi
A2 - Kusumaningsih, Triana
PB - American Institute of Physics Inc.
T2 - 14th Joint Conference on Chemistry 2019, JCC 2019
Y2 - 10 September 2019 through 11 September 2019
ER -