Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea- p -toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA)

Kautsar Ul Haq, Septi Rosiana Dewi, Sherly Dwi Cicilianingrum, Amalia Muti Anggraini, Zella Dwipuspita Dahana, Indrianti Yunita Sari, Rina Dewi Renjanawati, Januardi Wardana, Fandi Gunawan, Nuzilatul Muschafi, Nisa'Ur Rosyidah, Hery Suwito

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Derivatives of 5-benzylidenehydantion are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. The preparation methods of 5-benzylidenehydantoin and 5- benzylidenecreatinine derivatives obtained from the reaction between aromatic aldehydes with hydantoin or creatinine using Knoevenagel condensation are discussed. Performing the reactions, we used mixed catalysts system that were Urea- p-Toluene sulfonic acid (Urea-PTSA) and Guanidine hydrochloride-triethylamine (GnHCl-TEA) in polyethylene glycol as solvent. The reaction conditions were suitable for the reaction of aromatic aldehydes attaching electron donating substituent, as well as electron withdrawing substituents. Catalyst system of Urea-PTSA furnished best yield for rich electron aldehydes, while catalyst system of GnHCl-TEA were suitable for poor electron aldehydes and heteroaromatic aldehydes.

Original languageEnglish
Title of host publication14th Joint Conference on Chemistry 2019
EditorsFitria Rahmawati, Teguh Endah Saraswati, Khoirina Dwi Nugrahaningtyas, Soerya Dewi Marliyana, Triana Kusumaningsih
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419964
DOIs
Publication statusPublished - 2 Jun 2020
Event14th Joint Conference on Chemistry 2019, JCC 2019 - Surakarta, Indonesia
Duration: 10 Sep 201911 Sep 2019

Publication series

NameAIP Conference Proceedings
Volume2237
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference14th Joint Conference on Chemistry 2019, JCC 2019
Country/TerritoryIndonesia
CitySurakarta
Period10/09/1911/09/19

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