Synthesis, In Vitro anticancer activity and In Silico study of some benzylidene hydrazide derivatives

Melanny Ika Sulistyowaty, Galih Satrio Putra, Tutuk Budiati, Katsuyoshi Matsunami

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Some benzylidene hydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70-99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9 µg/mL, which was linear with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.

Original languageEnglish
Title of host publicationSymposium of Materials Science and Chemistry II
EditorsTutik Dwi Wahyuningsih, Roto Roto, Dwi Siswanta, Rohana Adnan, Laurent Commeiras, Kuwat Triyana, Kuwat Triyana, Indriana Kartini, Julius Motuzas
PublisherTrans Tech Publications Ltd
Pages277-283
Number of pages7
ISBN (Print)9783035716139
Publication statusPublished - 2020
Event5th International Conference on Science and Technology, ICST 2019 - Yogyakarta, Indonesia
Duration: 30 Jul 201931 Jul 2019

Publication series

NameKey Engineering Materials
Volume840 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference5th International Conference on Science and Technology, ICST 2019
Country/TerritoryIndonesia
CityYogyakarta
Period30/07/1931/07/19

Keywords

  • A549 cell line
  • Benzylidene hydrazides
  • Docking study
  • Synthesis
  • Tyrosine kinase

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