TY - GEN
T1 - Synthesis, In Vitro anticancer activity and In Silico study of some benzylidene hydrazide derivatives
AU - Sulistyowaty, Melanny Ika
AU - Putra, Galih Satrio
AU - Budiati, Tutuk
AU - Matsunami, Katsuyoshi
N1 - Publisher Copyright:
© 2020 Trans Tech Publications Ltd, Switzerland.
PY - 2020
Y1 - 2020
N2 - Some benzylidene hydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70-99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9 µg/mL, which was linear with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.
AB - Some benzylidene hydrazides (3a-e) have been synthesized in three reaction steps from anthranilic acid in good yields, about 70-99%. The structures of the synthesized compounds were analyzed using spectroscopic methods. The compounds were evaluated its activity against human lung cancer, A549 cell line by MTT method and studied its molecular docking onto the protein tyrosine kinase (PDB ID: 1M17) by using Molegro® vs. 5.5. The data showed that N-(2-(2-(4-nitrobenzylidene)hydrazinecarbonyl)phenyl)benzamide (3d) which synthesized in 70% yield and has the highest activity on inhibiting the growth of A549 cell line with IC50 10.9 µg/mL, which was linear with our in silico study. Compound 3d has the smallest RS value -94.44 kcal/mol, lower than selected Ligand, Erlotinib.
KW - A549 cell line
KW - Benzylidene hydrazides
KW - Docking study
KW - Synthesis
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=85085213738&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85085213738
SN - 9783035716139
T3 - Key Engineering Materials
SP - 277
EP - 283
BT - Symposium of Materials Science and Chemistry II
A2 - Wahyuningsih, Tutik Dwi
A2 - Roto, Roto
A2 - Siswanta, Dwi
A2 - Adnan, Rohana
A2 - Commeiras, Laurent
A2 - Triyana, Kuwat
A2 - Triyana, Kuwat
A2 - Kartini, Indriana
A2 - Motuzas, Julius
PB - Trans Tech Publications Ltd
T2 - 5th International Conference on Science and Technology, ICST 2019
Y2 - 30 July 2019 through 31 July 2019
ER -
