Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic

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Abstract

Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,1H-NMR,13C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate.

Original languageEnglish
Pages (from-to)297-298
Number of pages2
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume8
Issue number6
Publication statusPublished - 2016

Keywords

  • 1-allyl-3-(2-chlorobenzoyl)thiourea
  • Analgesic activity
  • Modified schotten-baumann

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