Synthesis and Characterization Scaffold Chitosan / Poly (ε-caprolactone) as Candidate for Skin Tissue Engineering in Burns

Introduction: The development of skin tissue engineering as an alternative for burn therapy has advantages over biological dressing. Using Polycaprolactone (PCL) with chitosan in skin tissue engineering is expected to produce materials that meet the standards in skin tissue engineering. This research aims to study the variations of PCL in chitosan/PCL skin tissue engineering. Methods: From the Fourier-transform infrared spectroscopy (FTIR) results, there were no difference in functional groups between four chitosan/PCL samples with variations in PCL concentration. They were all non toxic due to cytotoxicity assay. Results: The addition of PCL concentration also decreases the samples degradation rate but increases the sample contact angle. Conclusion: Based on these results, chitosan/PCL composites can be product innovation for skin tissue engineering based on the characteristics of fiber size, tensile strength, degradation rate, and biocompatibility.