Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia

Jin Woong Yoon; Eunkyung Kim; Narae Jeong; Minseok Kang; Han Seul Kim; Seonjae Lee; Hyung Jun Yoon; Seung Gon Kim; Euihyeon Na; Hyunju Yang; Joon Hyuk Park; Shu Yu Yang; Shih Ku Lin; Xiaomin Zhu; Yu Tao Xiang; Kang Sim; Chay Hoon Tan; Sandeep Grover; Ajit Avasthi; Roy Abraham Kallivayalil; Margarita M. Maramis; Kok Yoon Chee; Pornjira Pariwatcharakul; Tin Oo; Takahiro A. Kato; Afzal Javed; Mian Yoon Chong; Norman Sartorius; Naotaka Shinfuku; Jeongsoo Park; Seon Cheol Park

doi:10.1016/j.ajp.2024.104197

Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia

Jin Woong Yoon, Eunkyung Kim, Narae Jeong, Minseok Kang, Han Seul Kim, Seonjae Lee, Hyung Jun Yoon, Seung Gon Kim, Euihyeon Na, Hyunju Yang, Joon Hyuk Park, Shu Yu Yang, Shih Ku Lin, Xiaomin Zhu, Yu Tao Xiang, Kang Sim, Chay Hoon Tan, Sandeep Grover, Ajit Avasthi, Roy Abraham KallivayalilMargarita M. Maramis, Kok Yoon Chee, Pornjira Pariwatcharakul, Tin Oo, Takahiro A. Kato, Afzal Javed, Mian Yoon Chong, Norman Sartorius, Naotaka Shinfuku, Jeongsoo Park, Seon Cheol Park

Research output: Contribution to journal › Article › peer-review

Abstract

Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.

Original language	English
Article number	104197
Journal	Asian Journal of Psychiatry
Volume	101
DOIs	https://doi.org/10.1016/j.ajp.2024.104197
Publication status	Published - Nov 2024

Keywords

Asia
Lithium
Mood stabilizer
Network analysis
Suicidality
Unipolar depression

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10.1016/j.ajp.2024.104197

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Yoon, J. W., Kim, E., Jeong, N., Kang, M., Kim, H. S., Lee, S., Yoon, H. J., Kim, S. G., Na, E., Yang, H., Park, J. H., Yang, S. Y., Lin, S. K., Zhu, X., Xiang, Y. T., Sim, K., Tan, C. H., Grover, S., Avasthi, A., ... Park, S. C. (2024). Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia. Asian Journal of Psychiatry, 101, Article 104197. https://doi.org/10.1016/j.ajp.2024.104197

@article{f9c8b87c5f4a451f9d8b136706860492,

title = "Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia",

abstract = "Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.",

keywords = "Asia, Lithium, Mood stabilizer, Network analysis, Suicidality, Unipolar depression",

author = "Yoon, {Jin Woong} and Eunkyung Kim and Narae Jeong and Minseok Kang and Kim, {Han Seul} and Seonjae Lee and Yoon, {Hyung Jun} and Kim, {Seung Gon} and Euihyeon Na and Hyunju Yang and Park, {Joon Hyuk} and Yang, {Shu Yu} and Lin, {Shih Ku} and Xiaomin Zhu and Xiang, {Yu Tao} and Kang Sim and Tan, {Chay Hoon} and Sandeep Grover and Ajit Avasthi and Kallivayalil, {Roy Abraham} and Maramis, {Margarita M.} and Chee, {Kok Yoon} and Pornjira Pariwatcharakul and Tin Oo and Kato, {Takahiro A.} and Afzal Javed and Chong, {Mian Yoon} and Norman Sartorius and Naotaka Shinfuku and Jeongsoo Park and Park, {Seon Cheol}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = nov,

doi = "10.1016/j.ajp.2024.104197",

language = "English",

volume = "101",

journal = "Asian Journal of Psychiatry",

issn = "1876-2018",

publisher = "Elsevier B.V.",

}

Yoon, JW, Kim, E, Jeong, N, Kang, M, Kim, HS, Lee, S, Yoon, HJ, Kim, SG, Na, E, Yang, H, Park, JH, Yang, SY, Lin, SK, Zhu, X, Xiang, YT, Sim, K, Tan, CH, Grover, S, Avasthi, A, Kallivayalil, RA, Maramis, MM, Chee, KY, Pariwatcharakul, P, Oo, T, Kato, TA, Javed, A, Chong, MY, Sartorius, N, Shinfuku, N, Park, J & Park, SC 2024, 'Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia', Asian Journal of Psychiatry, vol. 101, 104197. https://doi.org/10.1016/j.ajp.2024.104197

TY - JOUR

T1 - Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia

AU - Yoon, Jin Woong

AU - Kim, Eunkyung

AU - Jeong, Narae

AU - Kang, Minseok

AU - Kim, Han Seul

AU - Lee, Seonjae

AU - Yoon, Hyung Jun

AU - Kim, Seung Gon

AU - Na, Euihyeon

AU - Yang, Hyunju

AU - Park, Joon Hyuk

AU - Yang, Shu Yu

AU - Lin, Shih Ku

AU - Zhu, Xiaomin

AU - Xiang, Yu Tao

AU - Sim, Kang

AU - Tan, Chay Hoon

AU - Grover, Sandeep

AU - Avasthi, Ajit

AU - Kallivayalil, Roy Abraham

AU - Maramis, Margarita M.

AU - Chee, Kok Yoon

AU - Pariwatcharakul, Pornjira

AU - Oo, Tin

AU - Kato, Takahiro A.

AU - Javed, Afzal

AU - Chong, Mian Yoon

AU - Sartorius, Norman

AU - Shinfuku, Naotaka

AU - Park, Jeongsoo

AU - Park, Seon Cheol

PY - 2024/11

Y1 - 2024/11

N2 - Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.

AB - Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.

KW - Asia

KW - Lithium

KW - Mood stabilizer

KW - Network analysis

KW - Suicidality

KW - Unipolar depression

UR - http://www.scopus.com/inward/record.url?scp=85203273276&partnerID=8YFLogxK

U2 - 10.1016/j.ajp.2024.104197

DO - 10.1016/j.ajp.2024.104197

M3 - Article

AN - SCOPUS:85203273276

SN - 1876-2018

VL - 101

JO - Asian Journal of Psychiatry

JF - Asian Journal of Psychiatry

M1 - 104197

ER -

Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia

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Keywords

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