Successful treatment of intravenous immunoglobulin for Toxic Epidermal Necrolysis (TEN) associated with COVID-19 infection and vaccination: case reports

Background: Toxic Epidermal Necrolysis (TEN) are rare but potentially life-threatening disorder. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of COVID-19 disease with various clinical manifestations. Two cases of TEN were reported in pediatric patients. The causal relationship between COVID-19 infection and vaccination against TEN has not been fully understood. Case presentation: This study reports a case of a child with COVID-19 who was admitted to a pediatric hospital ward with TEN which occupies > 30% of total body surface area, and one case that suffered from TEN due to COVID-19 vaccination. All patients received IVIG 0.5 g / kg / day for 3 consecutive days. Conclusion: The child was treated with intravenous immunoglobulin with a good outcome and clinical improvement.