Amniotic membrane is used as a biomaterial in orthopedics, and its use keeps increasing. Another source of amnion can be found in bovine. Amniotic membrane in the sponge form is more easily applied to several types of wounds, is more durable, and can be used as an absorbent dressing for productive chronic wounds. This type of study is an analytic observational study that gives three different treatments to two different samples. The research design used is a randomized, post-test-only design. The bovine amnion was made into a membrane and sponge, and they were characterized based on thickness, water absorption, and tensile strength. The bovine amnion membrane has a tensile strength of 0.07 ± 0.006 N/mm2, while the bovine amnion sponge has a tensile strength of 0.118 ± 0.01 N/mm2, it has a significant result difference with a p-value of 0.001. In the absorption power test results, it was found that the bovine amnion sponge had an average absorption power of 0.84 ± 0.09 (1004 ± 122%), and the bovine amnion membrane had an absorption power of 0.80 ± 0.11 (806 ± 118%) with a p-value of 0.442. The average thickness of the bovine amnion membrane is 0.30 ± 0.01, and the thickness of the bovine amnion sponge is 0.61 ± 0.26; it also has a significant result difference with a p-value of 0.001. Bovine amnion sponges have better absorption capability and stronger tensile strength, while freeze-dried amnion membranes have a more homogeneous thickness.

Original languageEnglish
Pages (from-to)865-873
Number of pages9
JournalJournal of Medicinal and Pharmaceutical Chemistry Research
Issue number7
Publication statusPublished - Jul 2024


  • Amniotic
  • bovine
  • membrane
  • sponge


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